Comparative efficacy of miconazole nitrate, graphite, Thuja and Chrysorobin ointments was assessed against three keratinophillic fungi, viz., Trichophyton terrestris, Chrysosporium tropicum and Microsporum gypseum. All the test fungi were sensitive to the anti microbials tested in the present study. Miconazole nitrate, showed the maximum activity followed by Graphite, and Thuja, whereas the min...

A síntese, a caracterização espectroscópica e os resultados biológicos de novas séries de 2-(4-piridil)-1,2,3,4-tetrahidroquinolinas e seus precursores, -N-aril-N-[1-(4-piridil)but-3-enil] aminas, são descritos. Foi encontrado que ambos, precursores substituídos g-piridil e os produtos finais, as tetrahidroquinolinas, demonstraram excelentes atividades antifúngicas contra Aspergillus fumigatus,...

Dermatophytosis (tinea) infections are fungal infections caused by dermatophytes a group of fungi that invade and grow in dead keratin. Several species commonly invade human keratin and these belong to the Epidermophyton, Microsporum and Trichophyton genera. They tend to grow outwards on skin, producing a ringlike pattern hence the term 'ringworm'. They are very common and affect different part...

Cells of Candida parapsilosis were extracted sequentially with different organic solvents. The sodium carbonate wash of the methanol extract showed carcinogenic activity in mice as demonstrated by the appearance of 6 sarcomas at the site of injection in a group of 16 animals. Suggestive carcinogenic activity in the appearance of subcutaneous sarcomas and increased frequency of leukemias and pul...

Dermatophytoses are superficial infections of keratinized tissues like hair, skin and nail, caused by a specialized group of fungi closely related antigenically, physiologically and morphologically, known as dermatophytes or ringworm fungi (Rabell and Taplin, 1974). The etiologic agents of the dermatophytoses are classified in three anamorphic (asexual or imperfect) genera, Epidermophyton, Micr...

Antifungal activities of clove essential oil and its volatile vapour against dermatophytic fungi including Candida albicans, Epidermophyton floccosum. Microsporum audouinii, Trichophyton mentagrophytes, and Trichophyton rubrum were investigated. Both clove essential oil and its volatile vapour strongly inhibit spore germination and mycelial growth of the dermatophytic fungi tested. The volatile...

Hybridoma cells produced by fusing myeloma cells with spleen cells from mice immunized with a soluble antigen of Microsporum canis yielded 30 antibody-producing clones. Six of these clones, propagated as ascites tumors in mice, showed two different types of monoclonal antibodies. The type 1 monoclonal antibody reacted with 17 heterologous and 10 homologous dermatophyte antigens. Type 2 monoclon...

Ringworm is by far the most important animal skin disease transmissible to man. About 27 per cent of all dermatophytosis are due to species which are parasites of the lower animals and though the treatment of this kind of infection is usually simpler than that caused by anthropophilic species, the control of this infection in animals presents a special problem which calls for the co-operation o...

Investigations were carried out to evaluate the therapeutic properties of the seeds and leaves of Moringa oleifera Lam as herbal medicines. Ethanol extracts showed anti-fungal activities in vitro against dermatophytes such as Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis. GC-MS analysis of the chemical composition of the essential oil from lea...

Dermatophytes are fungi capable of invading keratinized tissues. Isolation of the fungus with the culture is essential to guide the treatment, because there are more resistant species like Microsporum canis. The chronic use of corticosteroids leads to the deregulation of immunity, promoting atypical manifestations of infections. Topical antifungal therapy is often insufficient, requiring system...