This paper is concerned with the adsorbate-induced phase transition model on a catalytic surface introduced by Hildebrand et al [2] and Mikhailov et al [3, 7]. They showed that microreactors with submicroreactor and nanometer sizes may spontaneously develop in surface chemical reactions by a non-equilibrium selforganization process. The self-organized micrometers represent localized structure r...

This work shows a simple way of producing fixed bed microreactors or packed microcolumns by using electrodynamic focusing. Based on previous results that showed fibre focalization on orifices is possible, we explored this technique to electrospun fibres inside microchannels. Different polymeric nanofibres either neat or composite, i.e. fibres containing particles can be deposited without meanin...

We introduce the use of immobilized enzymes in hydrogels for proteomic sample processing in digital microfluidic systems. In this technique, pre-formed cylindrical agarose discs bearing immobilized enzymes were integrated into digital microfluidic devices bearing arrays of electrodes. In some experiments, fluorogenic enzyme substrates were delivered to gel discs which served as integrated micro...

Liquid microchannels on structured surfaces are built up using a wettability pattern consisting of hydrophilic stripes on a hydrophobic substrate. These channels undergo a shape instability at a certain amount of adsorbed volume, from a homogeneous state with a spatially constant cross section to a state with a single bulge. This instability is quite different from the classical Rayleigh Platea...

Over the past year there have been a number of recent advances in the fields of miniaturized reaction and separation systems, including the construction of fully integrated 'lab-on-a-chip' systems. Microreactors, which initially targeted DNA-based reactions such as the polymerase chain reaction, are now used in several other chemical and biochemical assays. Miniaturized separation columns are c...

We present a general inexpensive method for realizing a Teflon stack microreactor with an integrated piezoelectric actuator for conducting chemical synthesis with solid products. The microreactors are demonstrated with palladium-catalyzed C-N cross-coupling reactions, which are prone to clogging microchannels by forming insoluble salts as by-products. Investigations of the ultrasonic waveform a...

Multiparameter flow cytometry is commonly used for the analysis of cells and droplet microreactors. However, their cost and complexity limits its applications in point-of-care systems. This paper demonstrates a high speed frequency multiplexed electronic detector for multicolor flow cytometry. The system can detect multiple fluorophores on a single PMT, rather than one per fluorophore. The dete...

A miniaturized approach was developed for quantitative permethylation of oligosaccharides, which involves packing of sodium hydroxide powder in microspin columns or fused-silica capillaries (500 microm i.d.), permitting effective derivatization in less than a minute at microscale. Prior to mass spectrometry, analytes are mixed with methyl iodide in dimethyl sulfoxide solution containing traces ...

This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new opportunities to reconsider the conventional approach for exothermic and selectivity sensitive nitration reactions. Four different approaches ...