Quantitative assays of all sorts are common to many applications in basic science and clinical research. Most of these assays require the movement, either addition or subtraction, of liquid reagents. Historically these assays were performed in test tubes. However, regardless of the assay method employed, laboratories requiring high throughput have often adapted the described protocol to a 96-we...

The synaptic enzyme acetylcholinesterase (AChE), which is the target of many insecticides and potential warfare agents, is implied in Alzheimer's disease and is a good potential candidate to be used in biosensors. This promotes a strong demand for production of recombinant AChE to be used in various studies. A promising expression system is the yeast Pichia pastoris, but the expression efficien...

We present statistical evidence for a temporal link between variations in the El Niño-Southern Oscillation (ENSO) and the occurrence of earthquakes on the East Pacific Rise (EPR). We adopt a zero-inflated Poisson regression model to represent the relationship between the number of earthquakes in the Easter microplate on the EPR and ENSO (expressed using the southern oscillation index (SOI) for ...

and Implications The data indicated a positive correlation exists between in vitro adherence capability and in vivo pathogenicity of M. hyopneumoniae clones. Results obtained with the in vitro microtiter plate adherence assay indicated that it can be used to estimate the pathogenicity of strains. However, low adherence capability and possibly pathogenicity were not stable as indicated by the sh...

The current investigation deals with proposing a numerical analysis for the geometrically nonlinear large-amplitude vibrations of arbitrary-shaped microplates having variable thickness various patterns in presence couple stress type microstructural size dependency. To accomplish this purpose, isogeometric (IGA) is employed to achieve exact geometrical description as well higher-order efficient ...