The use of vegetal extracts requires toxicological and genotoxic evaluations to establish and verify safety before being added to human cosmetic, pharmaceutical medicine, or alimentary products. Persea americana seeds have been used in traditional medicine as treatment for several diseases. In this work, the ethanolic seed extract of Persea americana was evaluated with respect to its genotoxic ...

Hospital effluents are serious problems in developing countries like Brazil, and when not treated adequately, can cause mutagenic effects on live organisms. Biomonitors, like Allium cepa L., which is one of the most used plant species when monitoring effluent genotoxicity, have been used to alert the world population about environmental contamination and genotoxic chemical emissions. The Allium...

Petroleum refinery wastes contain mixtures of toxic compounds including Polycyclic Aromatic Hydrocarbons (PAH) which may pose genotoxic threats to the biota. The objective present study was assess potential wastewaters petroleum at Sapugaskanda, Sri Lanka using erythrocytic micronuclei and nuclear abnormalities as biomarkers in fish Oreochromis niloticus exposed wastewater under controlled labo...

Pesticides are considered to be one of the biggest economic and ecological problems in aquatic ecosystem. Monitoring for toxic effects screening different insecticides is vital crucial reducing adverse on organisms public health. Therefore, this study, we aimed determine genotoxic effect acetamipridine a model fish species, Cyprinus carpio, using micronucleus test Comet assay. Common carp (aver...

Crude oil is enriched in polycyclic aromatic hydrocarbons (PAHs). Many PAH analogs have proved to potentially damage DNA. DNA damage can be assessed using various biomarkers to find out the degree of genotoxicity of pollutants following in vitro exposure. In this research the comet assay and micronucleus (MN) test were used to detect DNA damages and cytogenetic changes following crude oil expos...

Micronuclei are small membrane-enclosed cytoplasmic bodies containing whole or fragmented chromosomes, which are formed during anaphase in aberrant mitosis and in response to genotoxic stress. in the latter scenario, the formation of micronuclei can be used to assess the toxicity of various chemicals and drugs. A report by Rello-varona et al. in a previous issue describes the elimination of mic...

The genotoxic effects of three 1,3-butadiene metabolites, 1,2-epoxy-3-butene (monoepoxide, EB), 1,2,3,4-diepoxybutane (diepoxide, DEB) and 1,2-dihydroxy-3,4-epoxybutane (diolepoxide, DiolEB), on male rat germ cells were studied by the meiotic micronucleus method in vitro. Seminiferous tubular segments from stages XII to XIII containing late pachytene-diakinetic spermatocytes were cultivated in ...