*Department of Radiation Oncology, New York University School of Medicine, New York, New York; yDepartment of Radiation Oncology, University of Alabama Health Services Foundation, South Birmingham, Alabama; zDepartment of Radiation Oncology, University of Pennsylvania, Philadelphia, Pennsylvania; xDepartment of Radiation Oncology, University of Michigan, Ann Arbor, Michigan; kDepartment of Radi...

Department of Biophysics, University of Michigan, Ann Arbor, MI 48109 Whitehead Institute for Biomedical Research, and Department of Biology, MIT, Nine Cambridge Center, Cambridge, MA 02142 Department of Biological Sciences, Virginia Polytechnic Institute & State University, Blacksburg, VA 24061 Cell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109 *Correspond...

Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation Erik J. Eide, Margaret F. Woolf, Heeseog Kang, Peter Woolf, William Hurst, Fernando Camacho, Erica L. Vielhaber, Andrew Giovanni, and David M. Virshup* Department of Oncological Sciences and the Center for Children, Huntsman Cancer Institute, and Division of Hematology/Oncology, Department of Pediatrics...

There are a sub-population of cells in tumor tissues known as cancer stem cells (CSCs) which have similar features with stem cells, including self-renewal and differentiation capacity. Recently, it was established that not only stem cells factors such as Oct4, but also ES-associated lncRNAs are contributing to various regulatory aspects of CSCs. Myocardial infarction associated transcript (MIAT...

A Susceptibility Locus on 1p32–1p34 for Congenital Macrostomia in a Chinese Family and Identification of a Novel PTCH2 Mutation Zhipeng Fan, Juan Du, Huimin Liu, Honglai Zhang, Andrzej A Dlugosz, Cun-Yu Wang, Ming Fan, Yan Shen, and Songlin Wang* Molecular Laboratory for Gene Therapy, Capital Medical University School of Stomatology, Beijing, PR China Department of Stomatology, Daqin Longnan Ho...

elevated expression of the drug efflux transporter abcg2 seems to correlate with multidrug resistance of cancer cells. specific cox-2 inhibitor celecoxib has been shown to enhance the sensitivity of cancer cells to anticancer drugs. to clarify whether abcg2 inhibition is involved in the sensitizing effect of celecoxib, we investigated whether the expression of abcg2 in breast cancer cell lines ...

The long-term effect of socioeconomic status (SES) and healthcare resources availability (HCA) on breast cancer stage of presentation and mortality rates among patients in Michigan is unclear. Using data from the Michigan Department of Community Health (MDCH) between 1992 and 2009, we calculated annual proportions of late-stage diagnosis and age-adjusted breast cancer mortality rates by race an...

Affiliations of authors: Internal Medicine and Pharmacology, University of Michigan Medical School, Ann Arbor, MI (JMR); Edith Sanford Breast Cancer Research, Sanford Health and Research, Sioux Falls, SD (BLJ); Department of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA (MR); Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX...

lentinan a polysaccharide from medicinal mushroom i.e lentinus, has been known to have anticancer properties. telomerase activity is not observed in normal healthy cells, whereas in cancerous cells telomerase expression is high. telomerase represents a promising cancer therapeutic target. we investigated the inhibitory effect of lentinan on telomerase reverse transcriptase gene (htert) which is...