In our current study, phytochemical analysis and antibacterial activity of leaf extracts T. parthenium were assessed. Qualitative screening was carried using standard procedures quantitative for estimation total phenolic content (TPC) determined by spectrophotometric method. The accomplished disc diffusion assay, determination minimum inhibitory concentration (MIC) bactericidal (MBC) against tw...

Highlights:1. Typhoid fever, a major health problem for developing countries, requires alternative therapy to reduce drug resistance.2. A. bilimbi, native plant of Indonesia, has antibacterial potential, which is effective against S. typhi in vitro. AbstractIntroduction: Some plants Indonesia have potential effects on and medication. This study aimed determine the effect Averrhoa bilimbi (A. bi...

Staphylococcus aureus and Pseudomonas aeruginosa are part of the human microbiota and are also important bacterial pathogens, for which therapeutic options are lacking nowadays. The combined administration of corticosteroids and antimicrobials is commonly used in the treatment of infectious diseases to control inflammatory processes and to minimize potential toxicity of antimicrobials, avoiding...

INTRODUCTION Tuberculosis continues to be a devastating public health problem. Many communities in Uganda use medicinal plants to treat various infections, including respiratory tract infections. There are claims that some can treat tuberculosis. Verifying some of these claims could lead to discovery of lead compounds for development of a TB drug. METHODS Chloroform and methanol extracts of L...

A novel and time-saving method for assessing bactericidal activities of beta-lactam antibiotics on agar plates is described. Minimal inhibitory concentrations (MICs) were determined by the agar dilution method. A potent beta-lactamase solution was sprayed onto the plates to inactivate the antibiotic. After further incubation at 37 degrees C overnight, the minimal concentration at which no visib...

The pharmacokinetics and pharmacodynamics of two multiple-dose regimens of piperacillin-tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 healthy adult volunteers. Inhibitory and bactericidal activities for the two regimens were determined with five American Type Culture Collection (ATCC) organisms (Escherichia coli, Staphylococcus aureus, Klebsiella pneum...

Nature is an unexplored reservoir of novel phytopharmaceuticals. Since biofilm-related oral diseases often correlate with antibiotic resistance, plant-derived antimicrobial agents could enhance existing treatment options. Therefore, the rationale of the present report was to examine the antimicrobial impact of Mediterranean natural extracts on oral microorganisms. Five different extracts from O...

The emergence of multidrug-resistant strains of Acinetobacter baumannii (MDRAB) constitutes a serious threat to public health and necessitates the discovery of new types of antimicrobial agents. Alyteserin-1c (GLKEIFKAGLGSLVKGIAAHVAS·NH(2)) is a cationic, α-helical peptide that was first isolated from skin secretions of the midwife toad Alytes obstetricans. Synthetic alyteserin-1c displayed pot...

Highlights:1. The COVID-19 pandemic makes personal hygiene more important than ever, and antibacterial substances such as disinfectants are crucial in maintaining said hygiene.2. MBC of cavendish banana peel extract against the growth bacteria Escherichia coli Staphylococcus aureus was 25%, with no activity Bacillus subtilis.3. Musa acuminata has potential to be used a disinfectant. AbstractInt...