The purpose of this systematic review was to investigate the effects of therapeutic radiopharmaceuticals in patients with different types of advanced neuroendocrine tumour (NETs). A literature search was carried out in MEDLINE and EMBASE from January 1998 to November 2010. The Cochrane Library (to Issue 10, 2010) and the Standards and Guidelines Evidence Inventory of Cancer Guidelines, includin...

radioiodinated meta iodobenzylguanidine (mibg) is one of the important radiopharmaceuticals in nuclear medicine. [123/131i]mibg is used for imaging of adrenal medulla, studying heart sympathetic nerves, treatment of pheochromacytoma and neuroblastoma. for clinical application, radioiodinated mibg is prepared through isotopic exchange method, which includes replacement of radioactive iodine in a...

The cardiac sympathetic nervous system in health and disease Anatomically the heart, particularly the left ventricular (LV) myocardium, has dense sympathetic innervation. Postganglionic neurons originate in the thoracic, stellate and cervical ganglia of the sympathetic chain, and run alongside the coronary arteries from the base to the apex of the heart, innervating myocardium and blood vessels...

A 70-year-old Japanese woman was referred to our hospital due to hyperhidrosis and rapid weight loss of 10 kg in a month. A lump measuring 26 mm in diameter was detected in the left adrenal gland by computed tomography. Biochemical tests showed high levels of serum and urinary norepinephrine and epinephrine. However, a (123)I-MIBG scintigram failed to detect any accumulation in the left adrenal...

UNLABELLED Postsurgically elevated or increasing serum calcitonin levels strongly suggest the presence of residual or recurrent medullary thyroid carcinoma (MTC). Several imaging modalities (sonography, MRI, CT, scintigraphy with different types of radiolabeled ligands, etc.) are routinely used in an attempt to localize tumorous tissue, but such efforts often fail. In the search for a more reli...

Background: Iodine-123 metaiodobenzylguanidine (123I-MIBG) myocardial scintigraphy has been accepted as one of the most useful methods for the diagnosis of Parkinson’s disease (PD). Moreover, the accumulated evidence has indicated that the heart-to-mediastinum (H/M) ratio correlates with the disease severity of hypokinesia/ bradykinesia and rigidity. The present report describes the wearing-off...

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BACKGROUND Interleukin 1β (IL 1β) levels are associated with prognosis in heart failure. The cardiac adrenergic activity as assessed by metaiodobenzylguanidine (I123 MIBG) scintigraphy along with exercise parameters are important predictors of prognosis. The relationship between these variables is not fully established. OBJECTIVE To evaluate the association of IL 1β levels with exercise and I...