BACKGROUND Cardiovascular disease continues to be the leading cause of death in women and men in the United States. This study aimed to investigate differences in characteristics between those women who died and survived an acute myocardial infarction (MI). METHODS This secondary analysis included 109 women. Demographic variables were extracted along with presenting MI symptoms, cardiovascula...

AIMS Myocardial CCN2/CTGF is induced in heart failure of various etiologies. However, its role in the pathophysiology of left ventricular (LV) remodeling after myocardial infarction (MI) remains unresolved. The current study explores the role of CTGF in infarct healing and LV remodeling in an animal model and in patients admitted for acute ST-elevation MI. METHODS AND RESULTS Transgenic mice ...

recurrent paroxysmal tachycardia was admitted to hospital because of chest pain. The electrocardiogram (ECG) on admission (Figure 1A) showed signs suggestive of an antero septal accessory pathway, as well as ST segment elevation in leads V1 through V4, aVL and aVR, with elevated levels of cardiac enzymes. This was consistent with a diagnosis of Wolff–Parkinson–White syndrome with acute myocardi...

OBJECTIVES This study was designed to examine whether ST segment elevation in posterior chest leads (V7 to V9) during acute inferior myocardial infarction (MI) identifies patients with a concomitant posterior infarction and whether these patients might benefit more from thrombolysis. BACKGROUND Because the posterior wall is faced by none of the 12 standard electrocardiographic (ECG) leads, th...

Definition of MI. Criteria for acute, evolving or recent MI. Either one of the following criteria satisfies the diagnosis for an acute, evolving or recent MI: 1) Typical rise and gradual fall (troponin) or more rapid rise and fall (CK-MB) of biochemical markers of myocardial necrosis with at least one of the following: a) ischemic symptoms; b) development of pathologic Qwaves on the ECG; c) ECG...

Background—KAI-9803, a -protein kinase C inhibitor, has been shown to ameliorate injury associated with ischemia and reperfusion in animal models of acute myocardial infarction (MI). Methods and Results—Direct Inhibition of -Protein Kinase C Enzyme to Limit Total Infarct Size in Acute Myocardial Infarction (DELTA MI) was a “first-in-human,” dose-escalation study that evaluated the safety, toler...

Background The mitral apparatus contains two myocardial components papillary muscles and the adjacent left ventricular (LV) wall. Delayed enhancement CMR (DE-CMR) enables in-vivo study of potential contributions of LV wall and papillary muscle infarction (PMI) to MR. This study examined the relative impact of papillary muscle and LV wall infarction on mitral regurgitation (MR) following ST elev...

Background Myocardial oedema has been described as a marker of prognosis in ischaemic heart disease and CMR is able to characterise this using T2-weighted sequences. The inherent low signal to noise ratio of these sequences and low contrast between normal and abnormal myocardium makes quantification technically challenging. We therefore compared 5 methods of analysis in patients following reper...