We report successful use of methyl-prednisolone in a 21-month old child with ARDS that did not improve with conventional therapy. The child improved and could be extubated after 10 days of methylprednisolone therapy. Subsequently, the child was weaned off supplementary oxygen. Methylprednisolone appeared to be safe and effective in a child with unresolving ARDS.

The combination of high dose methylprednisolone and rituximab induces superior overall (93%) and complete (14%) response rates compared to high dose methylprednisolone alone (overall 43%, complete remission 0%) in heavily pre-treated chronic lymphocytic leukemia patients with advanced disease. Despite its efficacy the combination is not easily manageable because of the high rate of opportunisti...

An 8 year old girl with ocular myasthenia gravis was treated with high dose intravenous immunoglobulin and high dose intravenous methylprednisolone. Ocular symptoms recurred seven months after the start of the immunoglobulin. She has been in remission for more than 12 months after two courses of intravenous methylprednisolone, and administration of oral prednisolone was discontinued.

glucocorticoid steroids are widely used as anti-inflammatory and immunosuppressive medications and are well known to induce osteoporosis. in present study 24 rats were randomly divided into four groups (n=6): group a (control), group b (sham)that was treated only by normal saline for 1 month.group c that was treated by methylprednisolone acetate alone (0.2 mg/kg) for 1 month. group d that was t...

conclusions corticosteroid pulse therapy in spms was effective in inflammatory process, but could not postpone or decline the neurodegenerative process and besides the imposing side effects could not result in significant improvement in edss and mri plaques number in long term. patients and methods a double blind randomized controlled clinical trial was performed on 71 patients with spms referr...

This study was conducted to investigate the correlation between lipid-lowering and bone-protective effects of eicosapentaenoic acid on steroid-induced bonechanges in rats. Twenty-one male 10-week-old Wistar rats were divided into 3 groups (n = 7 each) and treated with 0.9% NaCl SC (group 1) or methylprednisolone 7 mg/kg SC once a week (group 2) or methylprednisolone 7 mg/kg SC once a week + eic...

Background and Objective: Due to the severe inflammatory conditions and cytokine storm in COVID-19 disease, corticosteroids are used worldwide as adjunctive therapy for these patients due to their anti-inflammatory effects. However, due to limited and inconsistent information about the effectiveness of this drug, this study aimed to investigate the benefit of combined use of β-interferon and me...