Collagen synthesis, content, and concentration were determined in the hypertrophied intima media of thoracic aortas from 10-, 15-, and 20-week-old spontaneously hypertensive rats (SHR). Although the rates of aortic collagen synthesis declined with age, the dry weight of the intima media and the total collagen content increased proportionally. Collagen concentration thus remained unchanged. Meth...

THE decarboxylase-inhibiting, sedative, and antihypertensive properties of amethyl-3,4-dihydroxy-DI,-phenylalanine (DL-amethyl-dopa) in man were first reported from this department in 1960.1 It was shown subsequently that these three properties of the compound reside solely in the L isomer (methyldopa, Aldomet) .2, 3 Numerous favorable reports on the use of methyldopa in the treatment of hypert...

Introduction Although methyldopa has been widely used in the treatment of hypertension for many years there is only a single case report (Yamadori and Albert, 1972) of bilateral choreoathetotic movements possibly related to treatment with this drug. That isolated case report was of a patient with concomitant severe bilateral cerebrovascular disease. The authors report here a similar case but in...

Albino Wistar rats (either sex, 225 to 250 g) were anesthetized with Sodium pentobarbitone (50 mg/kg, i.p.). Blood pressure was measured with a pressure transducer (T301) on a INCO polygraph through a polypropylene cannula placed in the carotid artery. A polypropylene cannula introduced in the jugulat vein was used for the infusion of drugs. In this study we have tried to ascertain the effect o...

Meacock SCR, Kitchen EA, Dawson W. Effects of benoxaprofen and some other non-steroidal anti-inflammatory drugs on leucocyte migration. European J'ournal of Rheumatology and Inflammation 1979 ;3 :23. 2 Collum LMT, Bowen DI. Ocular side effects of ibuprofen. BrJ' Ophthalmol 1971;55:472-7. 3 Palmer CAL. Toxic amblyopia from ibuprofen. Br MedJ 1972;iii:765. 4 Melluish JW, Brooks CD, Ruoff G, Cross...

The adrenergic blocking agent methyldopa (Aldomet) is toxic to C-1300 neuroblastoma cells in vivo. Four injections of Aldomet at a dose of 7.5 mg/injection were given over a period of 24 hr to C-1300 neuroblastoma-bearing mice. This treatment killed a significant proportion of the C-1300 neuroblastoma cells. Flow cytometric data suggest that sensitivity of tumor cells to Aldomet is not related ...