BACKGROUND The heterochromatin of many eukaryotes is marked by both DNA methylation and histone H3 lysine 9 (H3-K9) methylation, though the exact relationship between these epigenetic modifications is unknown. In Neurospora, H3-K9 methylation is required for the maintenance of all known DNA methylation. In Arabidopsis, H3-K9 methylation directs some of the CpNpG and asymmetric methylation. Howe...

Genome-Wide Association Studies (GWAS) have identified genetic variants contributing to the risk of cardiovascular disease (CVD) at the chromosome 9p21 locus. The chromosome 9p21 is an important susceptibility locus for several multifactorial diseases like ischemic stroke, aortic aneurysm, type 2 diabetes mellitus and coronary artery disease (CAD). F7 gene because of its role in activating the ...

Lysine methylation of the p65 subunit of nuclear factor κB (NF-κB) on K218 and K221 together or K37 alone strongly enhances gene expression in response to cytokines. We analyzed the effects of K-to-Q mutations in the REL homology domain of p65 on the response to IL-1β in 293 cells with low levels of p65. The K218/221Q mutation greatly reduced the expression of 39 of 82 genes, whereas the K37Q m...

Coronary heart disease (CHD) is preventable, but the methods for assessing risk and monitoring response rely on imprecise lipid-based assessments. Recently, we have shown that an integrated genetic–epigenetic test includes three methylation-sensitive digital PCR assays predicts 3-year incident CHD better than methods. However, whether methylation sites change in to therapies alter not known. Th...

Prevention of chronic hepatitis C (CHC) and its complications is based on antiviral therapy early detection reliable molecular markers in persons under risk. We investigated whether the methylation status RASSF1A p16 genes, alone or combination with host viral factors, affects response to pegylated interferon/ribavirin (PEG-IFN/RBV). Methylation-specific polymerase chain reaction (MSP) was used...

It is suspected that environmental exposure to non-syndromic oral clefts, which includes cleft lip (CL), and palate (CLP) has an effect on epigenetic mechanisms, particularly deoxyribonucleic acid (DNA) methylation. DNA methylation will be expressed during facial morphogenesis have impact development. This study aimed observe differences in between CL CLP, mothers CLP mothers, correlation mothe...

Introduction and Aim: Genetic epigenetic factors affect chronic myeloid leukemia (CML) treatment response. This study aimed to investigate HOXA5 methylation gene expression with Imatinib mesylate (IM) response in CML patients assess their predictive value as markers. Materials Methods: Blood samples were collected from 50 (25 responders 25 non-responders mesylate) healthy controls of the same a...

Abstract Background The main epigenetic event occurring during the bladder carcinogenesis process is DNA methylation, affecting genes involved in various metabolic pathways and cell regulation. use of biological fluids such as urine sediments could be used a non-invasive approach to enhance cancer management. In this study, we aim determine promoter methylation status panel on tumor biopsies ev...

Future studies should shed new light on the complex relationship between HPTMs and human development. In particular, the molecular function of EZH2 and NSD1 in bone development should be addressed. Moreover, histone methylation and demethylation may be modulated by novel small molecule inhibitors[10, 11], which may pave the way to a therapeutic approach for those rare syndromes.