Objective: Substance dependence is the most critical biopsychosocial and legal problem. It has various harmful effects at the individual, familial, and society levels. The current study aimed to determine the effect of mindfulness-based cognitive therapy on reducing the intensity of substance dependence and improving cognitive emotion regulation in substance-dependent patients under methadone m...

Background and aims: Sexual dysfunction is a common complaint among drug abusers in the treatment with Methadone and Buprenorphine. The aim of this study was to assess sexual dysfunction in patients undergoing Methadone or Buprenorphine for maintenance therapy. Methods: This research was a cross-sectional study. A 3-parts questionnaire (demographic questi...

BACKGROUND Several types of medications have been used for stabilizing heroin users: Methadone, Buprenorphine and levo-alpha-acetyl-methadol (LAAM.) The present review focuses on the prescription of heroin to heroin-dependent individuals. OBJECTIVES To compare heroin maintenance to methadone or other substitution treatments for opioid dependence regarding: efficacy and acceptability, retainin...

BACKGROUND Methadone may cause respiratory depression and fatalities. Concomitant use of benzodiazepines in methadone-treated patients for chronic pain or as maintenance therapy for opiate abuse is common. However, the exact contribution of benzodiazepines to methadone-induced respiratory toxicity remains debatable. METHODS We investigated the respiratory effects of the combination diazepam (...

background: in iran, methadone has been used for methadone maintenance treatment (mmt) as well as analgesic treatment in pain clinics. recently, there are some reports regarding accidental and intentional methadone poisonings and deaths. the aim of this study was to evaluate the trend of methadone poisonings and deaths during a 10-year period in tehran, iran. methods: this was a retrospective c...

Legislation has enabled physicians to treat opioid-dependent patients with an office-based maintenance program using buprenorphine, a partial mu-opioid receptor agonist. Clinical studies indicate buprenorphine effectively manages opioid addiction. Buprenorphine is more effective than placebo for managing opioid addiction but may not be superior to methadone if high doses are needed. It is compa...

BACKGROUND Opioid dependence (OD) is a chronic, relapsing condition representing a significant societal burden in Asia. Opioid maintenance treatment (OMT) in combination with psychosocial treatment is considered to be the most effective strategy to treat opioid dependence. In Malaysia, about 52,000 patients reported receiving OMT in December 2012. OBJECTIVE The International Survey Informing ...

To evaluate driving aptitude and traffic-relevant performance at peak and trough medication levels in opioid-dependent patients receiving maintenance therapy with either buprenorphine (mean: 13.4 mg) or methadone (52.7 mg) and a medication-free control group, the Addiction Clinic at Medical University Vienna conducted a prospective, open-label trial where 40 opioid-dependent patients maintained...