Various treatments have been considered as the cornerstone for management of patients with metastatic renal cell carcinoma (mRCC) over past two decades. Currently, immunotherapy is a promising clue in landscape frontline treatment mRCC. Immune checkpoint inhibitors (ICIs), which constitute standard therapy pretreated mRCC patients, are emerging … Continued

UNLABELLED AIMS AND BACKGROUND; Hepatic tissues, including bile canaliculi and sinusoids, around primary or metastatic tumors are destructed and regenerate associated with tumor growth, and may show some phenotypic changes. The present study was undertaken to examine the expression of CD10 in bile canaliculi [CD10(BC)] and CD105 (endoglin) along hepatic sinusoids [CD105(HS)] in peritumoral hepa...

PURPOSE To assess the current treatment of metastatic renal cell carcinoma, focusing on medical treatment options. MATERIAL AND METHODS The most important recent publications have been selected after a literature search employing PubMed using the search terms: advanced and metastatic renal cell carcinoma, anti-angiogenesis drugs and systemic therapy; also significant meeting abstracts were co...

Metastatic testicular cancers are rare. Primary tumor sources are prostate, lung, and gastrointestinal tract for metastatic testicular cancers. Metastasis of urothelial carcinoma (UC) to the testis is extremely rare. Two-thirds of upper tract urothelial carcinoma (UTUC) is of invasive stage at diagnosis and metastatic sites are the pelvic lymph nodes, liver, lung, and bone. We report a rare cas...

Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) biopsy sampling of enlarged lymph nodes is increasingly used to diagnose metastatic tumors, especially of the gastrointestinal tract and the lungs. Herein, we describe the diagnosis of metastatic renal cell carcinoma from a native kidney of a 54 year-old male patient, who had a 5-years history of renal transplant, by EUS-FNA of media...

UNLABELLED BACKGROUND Targeted therapies in renal cell carcinoma can have different effects on primary and metastatic tumors. To pave the way for predictive biomarker development, we assessed differences in expression of targets of currently approved drugs in matched primary and metastatic specimens from 34 patients. METHODS Four cores from each site were embedded in tissue microarray bloc...

BACKGROUND Bladder small cell carcinoma is an uncommon tumour. Through a retrospective study we will present the evolution of recurrent and metastatic disease and outcome of patients treated at Léon-Bérard Cancer Centre. METHODS Only 15 patients having recurrent or metastatic bladder small cell carcinoma were treated at Léon-Bérard Cancer Centre between 1996 and 2007. The patients were divide...

Metastatic carcinoma from extragenital sites to the uterus, particularly endometrium, is rare and usually a sign of advanced disease. It necessary differentiate between metastatic primary tumours since treatment prognosis are entirely different. We discuss case 61-year-old woman who presented with postmenopausal bleeding due breast cancer endometrium. She had been diagnosed on tamoxifen for six...

Bladder carcinoma is one of the most common urological malignancies with many rare histological variants associated various prognosis. The recognition these bladder may be helpful in selecting appropriate therapeutic approach and to predict prognosis patients. We present three such entities urothelial squamous differentiation, cell metastatic which are bad

Vascular invasion is characteristic for follicular carcinoma of the thyroid and distant metastasis common. Spinal cord compression due to metastases differentiated as initial presentation an extremely rare condition. We report a case asymptomatic metastatic cancer which presented with spinal compression. This patient metastasized narrowing airway posed many challenges anesthetist.