Modular organization in biological networks has been suggested as a natural mechanism by which a cell coordinates its metabolic strategies for evolving and responding to environmental perturbations. To understand how this occurs, there is a need for developing computational schemes that contribute to integration of genomic-scale information and assist investigators in formulating biological hyp...

The last decade of biomedical research has been impacted by the appearance of systems biology, an analytical approach to complex biological systems that makes use of the ‘-omics’, that is, high-throughput technologies that allow the comprehensive characterisation of genes (genomics), RNA transcripts (transcriptomics) or proteins (proteomics). Since their appearance, the ‘omics’ held promise of ...

Salinity is a major concern in several ecosystems and has significant impact on global agriculture. To increase the sustainability of horticultural food systems, better management usage saline water soils need to be supported by knowledge crop-specific responses tolerable levels salinity. The aim this work was study effects mild salinity morphological growth development, leaf color, mineral com...

BACKGROUND Metabolomics is a tool that has been used for the diagnosis and prognosis of specific diseases. The purpose of this study was to examine if metabolomics could be used as a potential diagnostic and prognostic tool for H1N1 pneumonia. Our hypothesis was that metabolomics can potentially be used early for the diagnosis and prognosis of H1N1 influenza pneumonia. METHODS 1H nuclear magn...

Purpose Early diagnosis of leptomeningeal carcinomatosis (LMC) is necessary to improve outcomes of this formidable disease. However, cerebrospinal fluid (CSF) cytology is frequently false negative. We examined whether CSF metabolome profiles can be used to differentiate patients with LMC from patients having a risk for development of LMC. Results A total of 10,905 LMIs were evaluated using PC...

Würtz, PhD; Vuokko Kovanen, PhD; Sulin Cheng, PhD; Sarianna Sipilä, PhD; Mirja Hirvensalo, PhD; Risto Telama, PhD; Tuija Tammelin, PhD; Markku J. Savolainen, MD, PhD; Anneli Pouta, MD, PhD; Paul F. O’Reilly, PhD; Pekka Mäntyselkä, MD, PhD; Jorma Viikari, MD, PhD; Mika Kähönen, MD, PhD; Terho Lehtimäki, MD, PhD; 22,23 Paul Elliott, MB, PhD; Mauno J. Vanhala, MD, PhD; Olli T. Raitakari, MD, PhD; ...