The burgeoning obesity epidemic has fueled the drive to describe, mechanistically, metabolic homeostasis. From the early theories implicating glucose as a principal modulator grew an understanding of a complex array of metabolic signals, sensed by peripheral organs along with specific locations within the central nervous system (CNS). The discovery that leptin, an adipose-derived hormone, acts ...

UNLABELLED Acromegaly is a rare endocrine disease. Few studies have evaluated its association with hearing loss (HL) and the results are conflicting. AIM To evaluate the prevalence and features of HL in a group of patients being treated for acromegaly. To analyze peripheral and central auditory transmission. METHODS Cross-sectional study. A group of 34 patients with acromegaly were submitte...

The effects of TRH and its metabolite, histidyl-proline diketopiperazine (cyclo(His-Pro] on catecholamine metabolism in the central nervous system, peripheral tissues and plasma were examined in adult and young Wistar rats aged 3 weeks. The intravenous administration of 50 micrograms of TRH produced an increase in plasma epinephrine, cerebral dopamine and a reciprocal decrease in norepinephrine...

In this study, we investigate the relative organization of three (not independent) categorizations of metabolites—pathways, subcellular localizations and network clusters both qualitatively and quantitatively and further characterize the categories from topological point of view. The picture of the metabolism we obtain is that of peripheral modules, characterized both by being dense network clu...

Ghrelin is a gut-derived peptide and an endogenous ligand for the ghrelin receptor. Intravenous infusion of ghrelin induces insulin resistance and hyperglycemia and increases circulating levels of nonesterified free fatty acids. Our objective was to investigate whether the metabolic effects are mediated directly by ghrelin in skeletal muscle and adipose (peripheral and central) tissues. Ten hea...

INTRODUCTION Diabetic neurological complications continue to progress in a substantial fraction of patients despite best efforts at glycemic control. The development of adjuvant treatments to supplement diet, exercise, oral hypoglycemic agents, and insulin is urgently needed and may do much to enhance the quality of patient life. The neurobiology of insulin-like growth factors (IGFs) has been s...