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تعداد نتایج: 7154 فیلتر نتایج به سال:
High expression of the E26 transforming sequence related gene (ERG) is associated with poor prognosis in a subgroup of leukemia patients with acute myeloid (AML) and acute T-lymphoblastic leukemia (T-ALL). In a previous study we proposed that ERG overexpression may deregulate several signaling cascades in acute leukemia. Herein, we further expand those studies by identifying a consensus of biol...
Childhood acute myeloid leukemia (AML) is a heterogeneous disease, in terms of genetic/molecular abnormalities resulting into marked differences in outcome.1 A myriad of proteins have been suggested aberrantly regulated in AML, and Ets-related gene (ERG, 21q22) expression in normal and aberrant hematopoiesis is currently under evaluation.2 High ERG expression has been associated with poor progn...
Hormone-driven expression of the ERG oncogene after fusion with TMPRSS2 occurs in 30% to 70% of therapy-naive prostate cancers. Its relevance in castration-resistant prostate cancer (CRPC) remains controversial as ERG is not expressed in some TMPRSS2-ERG androgen-independent xenograft models. However, unlike these models, CRPC patients have an increasing prostate-specific antigen, indicating ac...
سابقه و هدف: این مطالعه به منظور بررسی اختلال راه عصب بینایی چشم با آزمایش الکترورتینوگرام (ERG) در بیماران مصرف کننده سیکلوسپورین ارجاع شده به کلینیک بصیر طی سالهای 95-94 انجام شد. روش بررسی: در این مطالعه مورد- شاهدی، 50 بیمار مصرف کننده سیکلوسپورین مراجعه کننده به کلینیک بصیر در سال 1394-1395 به صورت در دسترس انتخاب شده و تحت آزمون الکترورتینوگرافی قرار گرفتند. نتایج این آزمون شامل ولتاژ و ف...
The ERG gene belongs to the ETS family of transcription factors and has been found to be involved in atypical chromosomal rearrangements in several cancers. To gain insight into the oncogenic activity of ERG, we compared the gene expression profile of NIH-3T3 cells stably expressing the coding regions of the three main ERG oncogenic fusions: TMPRSS2/ERG (tERG), EWS/ERG and FUS/ERG. We found tha...
To the Editor: The recent article by Mosquera et al. reports TMPRSS2-ERG fusions in 46% of 100 trans-rectal biopsies of the prostate (TRBP) from prostate-specific antigen screened men in the United States (1) and compares this to the lower prevalence of ERG translocations in cancer detected incidentally on trans-urethral resection of the prostate (TURP). We agree with the authors that the lower...
Our purpose was to develop a new pharmacological approach for the treatment of prostate cancer (PCa), the most common neoplasia in men. Recently, we developed siRNA against the fusion oncogene TMPRSS2-ERG found in 50% of patients and showed an antitumoral activity in animal model. Herein, we want to compare or combine the developed siRNA to flutamide (FLU), one of the gold-standard treatment of...
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