introduction: acute myelogenous leukemia (aml) is a clonal  malignant disease of hematopoietic tissue. the early use of  hematopoietic stem cell transplantation (hsct) for aml was for patients with advanced stages of disease, usually while in relapse, in second or subsequent remission, or with resistant disease. patients and methods: from march 1991 until february 2008, 356(65%) registered allo...

from 1996 to 2002, fifty three patients with major beta-thalassemia received allogeneic peripheral blood stem cell trans plantation (pbsct). median age was 6 years .twenty two were class i, 17 class ii and 14 class iii. all of the donors were hla-identical. conditioning regimen for class i and ii patients consisted of cyclophosphamide (cy) 50 mg/kg/day for 4 days + busulfan (bu) 3.5 mg/kg for 4...

objectives the aim of this study was to investigate the effects of local cryotherapy on the intensity of chemotherapy-induced oral mucositis in autologous bone marrow transplantation patients. patients and methods in this single, blinded, randomized clinical trial, 29 patients undergoing stem cell transplantation in iran were selected by convenience sampling, and randomly allocated to control (...

Background  The mammary gland in humans is a dynamic organ that undergoes significant developmental changes during pregnancy, lactation, and involution. Stem cells derived from human breast milk possess the adult stem cell-like characteristics such as self-renewal, proliferative and differentiate potential. This source of stem cells avoids invasive procedures and the ethical controversy of emb...

Articles should focus on stem cell biology and may include the following topics: Stem cell properties § § Types, including hematopoietic stem cells, embryonic stem cells, mesenchymal stem cells and induced pluripotent stem cells, plasticity and immunophenotype. Stem cell biology § § Microenvironment niches, including bone marrow and fetal liver, gene regulation including that of transcription f...

Mesenchymal stem cells can be obtained from deferent tissues like adipose tissue, umbilical cord, placenta, skin, bone marrow, etc. These cells have regulatory effects on all types of immune cells such as dendritic cell, natural killers and lymphocytes. Mesenchymal stem cells induce inhibitory phenotypes of Antigen Presenting Cells (APCs) following their activity. They also change T cells pheno...

BACKGROUND In regenerative medicine, use of each of the mesenchymal stem cells derived from bone marrow, cord blood, and adipose tissue, has several cons and pros. Mesenchymal stem cells derived from cord blood have been considered the best source for precursor transplantation. Direct reprogramming of a somatic cell into induced pluripotent stem cells by over-expression of 6 transcription facto...

In the bone marrow, there are certain populations of stem cell sources with the capacity to differentiate into several different types of cells. Ideally, cell transplants would be readily obtainable, easy to expand and bank, and capable of surviving for sufficient periods of time. Bone marrow mesenchymal stem cells (BM-MSCs) possess all of these characteristics. One of the most important benefi...