نتایج جستجو برای: merkel cell polyomavirus
تعداد نتایج: 1686347 فیلتر نتایج به سال:
Merkel cell polyomavirus (MCPyV) is detected in approximately 80% of Merkel cell carcinomas (MCC). Yet, clonal integration and truncating mutations of the large T antigen (LTAg) of MCPyV are restricted to MCC. We tested the presence and mutations of MCPyV in highly purified leukemic cells of 70 chronic lymphocytic leukemia (CLL) patients. MCPyV was detected in 27.1% (n = 19) of these CLL cases....
Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication among tumor-derived MCV. We identified the hVam6p cytoplasmic protein involved in lysosomal processing as a novel interactor with MCV LT but no...
Affiliations 1. Michigan Center for Translational Pathology, University of Michigan Medical School 2. Department of Pathology, University of Michigan Medical School 3. Department of Dermatology, University of Michigan Medical School 4. Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, India 5. Department of Urology, Henry Ford Health System, Detroit, MI 6. Howard Hugh...
Recently, three novel human polyomaviruses KIPyV, WUPyV and MCPyV were uncovered in biological specimens of patients with different underlying clinical conditions. Although it is too early to draw firm conclusions on their role in human pathology, this finding has revitalized the scientific debate on the Polyomaviridae family and their relation to human disease. Seroepidemiological studies show...
Merkel cell polyomavirus (MCV), a previously unrecognized component of the human viral skin flora, was discovered as a mutated and clonally-integrated virus inserted into Merkel cell carcinoma (MCC) genomes. We reconstructed a replicating MCV clone (MCV-HF), and then mutated viral sites required for replication or interaction with cellular proteins to examine replication efficiency and viral ge...
R esearchers at the University of Pittsburgh Cancer Institute (UPCI), employing a new strategy to hunt for human viruses, have discovered a previously unknown virus strongly associated with a rare but deadly skin cancer called Merkel cell carcinoma. The strategy was described in a recent issue of the journal Science by UPCI’s Yuan Chang, Patrick Moore, Huichen Feng, and Masahiro Shuda. This is ...
Merkel cell carcinoma (MCC) is an aggressive poorly differentiated neuroendocrine cutaneous carcinoma associated with older age, immunodeficiency and Merkel cell polyomavirus (MCPyV) integrated within malignant cells. The presence of intra-tumoural CD8+ lymphocytes reportedly predicts better MCC-specific survival. In this study, the distribution of inflammatory cells and properties of CD8+ T ly...
Many viruses use overprinting (alternate reading frame utilization) as a means to increase protein diversity in genomes severely constrained by size. However, the evolutionary steps that facilitate the de novo generation of a novel protein within an ancestral ORF have remained poorly characterized. Here, we describe the identification of an overprinting gene, expressed from an Alternate frame o...
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