We compared the sensitivity and specificity of Typhidot-M and Widal test with blood culture (gold standard) for diagnosing typhoid fever in 105 children aged 1-15 years admitted with clinical suspicion of typhoid fever. Of the 105 cases, blood culture was positive for S.typhi in 41 (39%) children, Widal test was positive in 48 (45.7%) and Typhidot-M was positive in 78 (74.3%) cases. Sensitivity...

INTRODUCTION Enteric fever is a multisystemic infection which largely affects children. This study aimed to analyse the epidemiology, clinical presentation, treatment and outcome of paediatric enteric fever in Singapore. MATERIALS AND METHODS A retrospective review of children diagnosed with enteric fever in a tertiary paediatric hospital in Singapore was conducted from January 2006 to Januar...

Typhoid fever is an infection caused by a strain of bacteria called Salmonella typhi, which is related to the bacteria that causes salmonella food poisoning. The infection can affect the whole body and damage multiple organs. Unless treated, this infection can have life threatening consequences. A 20 year old girl was examined suffering from high fever from one week and abdominal pain for few d...

TO THE EDITOR—Our recent development of a human Salmonella Typhi challenge model provided a detailed description of the clinical profile and associated pathological changes seen during typhoid fever [1]. Alterations in hematological parameters included decreases in hemoglobin and hematocrit in all participants, and, in those diagnosed with typhoid, decreases in both platelet and total white cel...

The sensitivity and specificity of counterimmunoelectrophoresis using three antigenic preparations obtained from Salmonella typhi were compared with those of the Widal test in the serological diagnosis of typhoid fever. A veronal buffer extract yielded precipitation lines against 50 (96%) out of 52 sera collected from patients with typhoid but against none out of 62 sera obtained from control s...

BACKGROUND Post typhoid fever immune related reactions affecting the eye is a rare finding which can have various presentations in which typhoid retinopathy is not a well recognized sequelae. CASE PRESENTATION Here we present a case of 59 year old male who presented with right eye sudden painless loss of vision 4 weeks after typhoid fever which was diagnosed and treated successfully. His BCVA...

BACKGROUND Although thrombocytopenia is common in typhoid fever, its course, response to treatment, and need for specific therapies such as platelet transfusion are not well characterized. CASE PRESENTATION We report a case of typhoid fever in a 4-year-old Asian male returned traveler, admitted with prolonged fever and found to have severe thrombocytopenia (platelets 16 × 109/L). Despite appr...

The incidence of enteric (typhoid) fever in travelers is estimated to be approximately 3-30 cases per 100,000 travelers to developing countries. Recently, it is become clear that travelers who are visiting friends and relatives, especially travelers to the Indian subcontinent, seem to be the most vulnerable to enteric fever and require special attention for prevention. Recent concerns are the i...

INTRODUCTION Typhoid fever is one of the most common vaccine-preventable diseases in travellers returning from tropical destinations. However, immunity and the immune response to infection are barely understood. CASE PRESENTATION We report a case of tyhoid fever in a 29-year-old Caucasian, previously healthy woman who did not develop protective immunity or seroconversion of H or O antibodies ...

Background: Typhoid fever, caused by Salmonella typhi, is still a serious problem in many developing countries. It spread eating or drinking food water contaminated with the faeces of an infected person. Risk factors include poor sanitation and hygiene. This study presented mathematical model media campaign component to evaluate possible impact campaigns on typhoid fever awareness. Methods: Six...