Tumors of the soft membranes of the brain and spinal cord, especially those of a diffuse character, are comparatively rare~ and a careflll study of each individual example is of distinct value. The dollowing case was kindly offered me for study by Prof. Ludvig ttektoen, to whom I am indebted for much assistance in the preparation of my report. Primary tumor of cerebrum, secondary diffuse sarcom...

Recent histopathology studies suggest the presence of meningeal inflammation in patients with multiple sclerosis (MS) that might be associated with subpial cortical demyelination and a rather worse disease course.1 Although a radiologist is not a pathologist, diagnostic neuroradiology aims to visualize and to detect almost every (subtle) pathological feature of a disease to its full extent. To ...

SUMMARY Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain. These cells contain melanosomes of all four stages of development a...

Extracranial and meningeal seeding of glioblastoma multiforme is rare. We report herein a case of glioblastoma in a 41-year-old man who underwent surgical resection, concomitant chemoradiotherapy (CCRT) and seven courses of adjuvant chemotherapy with temozolomide. The patient then complained of intermittent severe lower back pain and gait disturbance. Imaging studies demonstrated that although ...

Primary meningeal melanomatosis is a rare, aggressive variant of primary malignant melanoma of the central nervous system, which arises from melanocytes within the leptomeninges and carries a poor prognosis. We report a case of primary meningeal melanomatosis in a 17-year-old man, which was diagnosed with (18)F-fluorodeoxyglucose (F-18 FDG) PET/CT, and post hoc F-18 FDG PET/MRI fusion images. W...

THE 354 cases dealt with in this study were treated in the Whiteabbey Hospital from late in 1947, when streptomycin first became available, to the end of 1956. 114 of the cases died. There were 76 cases of miliary disease alone, 160 cases of meningeal disease in which miliary spread was not (letected, and 118 cases of miliary and meningeal (lisease combined. TIhe age group with the highest inci...

OBJECTIVE To discuss the application of ARMS method to detect EGFR gene mutation in cerebrospinal fluid of lung adenocarcinoma patients with meningeal metastasis. METHODS 5 cases of lung adenocarcinoma were identified with meningeal metastasis that were cleared EGFR gene mutation by gene sequencing method. From each patient 5ml cerebrospinal fluid was obtained by lumbar puncture. ARMS method ...

The meninges have traditionally been viewed as specialized membranes surrounding and protecting the adult brain from injury. However, there is increasing evidence that the fetal meninges play important roles during brain development. Through the release of diffusible factors, the meninges influence the proliferative and migratory behaviors of neural progenitors and neurons in the forebrain and ...

An anatomical-angiographic classification for carotid-cavernous sinus fistulas is introduced and a series of 14 patients with spontaneous carotid-cavernous sinus fistulas is reviewed to illustrate the usefulness of such a classification for patient evaluation and treatment. Fistulas are divided into four types: Type A are direct high-flow shunts between the internal carotid artery and the caver...

Here, we report the existence of meningeal lymphatic vessels in human and nonhuman primates (common marmoset monkeys) and the feasibility of noninvasively imaging and mapping them in vivo with high-resolution, clinical MRI. On T2-FLAIR and T1-weighted black-blood imaging, lymphatic vessels enhance with gadobutrol, a gadolinium-based contrast agent with high propensity to extravasate across a pe...