نتایج جستجو برای: melphalan
تعداد نتایج: 4419 فیلتر نتایج به سال:
Background & Aims: Dendritic cells are the most potent antigen presenting cells in induction or polarization of T-dependent immune responses. In cancerous patients, suppressive or detoured immune responses regard to tumor cells, prevent appropriate functions of dendritic cells. Nowadays, in vitro production, expansion and maturation of dendritic cells in presence of safe maturation factors whi...
Autologous Stem Cell Transplantation (ASCT) is a standard of care in relapsed diffuse large B-cell lymphoma (DLBCL) and other lymphoproliferative disorders including relapsed Hodgkin’s disease, mantle or T-cell lymphoma. Carmustine, etoposide, ARA-C, melphalan (BEAM) [1], lomustine, etoposide, ARA-C, melphalan (LEAM) and lomustine, ARA-C, cyclophosphamide, etoposide (LACE) are commonly used con...
Purpose: The onset of drug resistance is a major cause of treatment failure in multiple myeloma. Although increasing evidence is defining the role of miRNAs in mediating drug resistance, their potential activity as drug-sensitizing agents has not yet been investigated in multiple myeloma. Experimental Design: Here we studied the potential utility of miR-221/222 inhibition in sensitizing refract...
Thirty-six out of sixty-two cases of myelomatosis have been treated with melphalan. Platelet counts were used as a guide to dosage early in the course of treatment, after which a more empirical dosage (0-15 mg/kg/ day) was used in 1-week courses given every 12 weeks. Rapid deterioration and death occur in a small number of patients whatever therapy is given. In the group treated with melphalan ...
In the majority of cases plasma cell leukaemia is a rapidly fatal disease with a mean survival time of five months. There have been reports of increased survival using various regimens of chemotherapy although most cases eventually relapse. We describe a patient with primary plasma cell leukaemia who responded to a combination of oral melphalan and prednisolone with control of the disease in th...
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