DANIEL J. KEVLES and LEROY HOOD (eds), The code of codes: scientific and social issues in the human genome project, Cambridge, Mass., and London, Harvard University Press, 1992, pp. x, 398, £23.95 (0-674-13645-4). The Human Genome Project (HGP) is Big Science. Simply put, its aim is to map all the genes found in human beings, a goal the molecular biologist Walter Gilbert has called the "grail o...

INTRODUCTION Academic medical centers today represent a unique fusion of traditional academia, hospital functions, several levels of education, and, above all, patients. They are complex organizations trying to discharge an often conflicting melange of responsibilities. This complexity has grown in recent years with the increasingly rapid rate of change (1), stressing both faculty and leadershi...

M. P. Searle's recent paper in the Journal of Structural Geology (Searle 1986) included a major departure from published structural interpretations of the Ladakh Himalaya. The geologic history of Ladakh is a vital key to understanding the timing and sequence of events during the Himalayan orogeny. Ophiolitic rocks and island arc volcanics along the Indus Suture zone (Frank et al. 1977, and many...

Astronauts Cernan and Schmitt, of Apollo 17, landed in the Taurus-Littrow valley of the Moon on December 11,1972. Their major objectives were (1) to sample very ancient lunar material such as might be found in pre-Imbrian highlands as distant as possible from the Imbrium basin and (2) to sample pyroclastic materials that had been interpreted as significantly younger than the mare basalts return...

Robo keeps axons moving F or migrating axons, attraction becomes repulsion with the fl ip of an alternatively spliced switch, according to Zhe Chen, Marc Tessier-Lavigne (Genentech Inc., San Francisco, CA), and colleagues. A melange of chemoattractants and repellants guides growing axons to their targets. Axons that cross the midline of the spinal cord on their way toward the nascent brain, how...

The only pillow basalt in synorogenic sedimentary rocks at the exterior margin of the Taconic orogen in eastern North America is at Stark’s Knob in eastern New York. Earlier reported as extrusive into allochthonous Ordovician slope and rise facies, this small lens (ca. 125+ m long, 39 m thick) is a fault-bounded block in Upper Ordovician melange under the Taconian frontal thrust. Its N-MORB (no...

16 AT A BLACK TIE PARTY at the Four Season’s in Manhattan last November 2005, the literary, social and business elite of New York gathered to mark the annual Kenyon Review award for literary distinction. The propinquity of New York wealth and philanthropy, with the glitterati of the publishing and literary world made for a special frisson. The atmosphere was further excited by the presence of M...

Robo keeps axons moving F or migrating axons, attraction becomes repulsion with the fl ip of an alternatively spliced switch, according to Zhe Chen, Marc Tessier-Lavigne (Genentech Inc., San Francisco, CA), and colleagues. A melange of chemoattractants and repellants guides growing axons to their targets. Axons that cross the midline of the spinal cord on their way toward the nascent brain, how...

The amacrine cell class comprises as many distinct cell subtypes as the rest of the retina combined. Though bewildering in their number and diversity, amacrine cells nonetheless often exhibit common morphological motifs and physiological features, suggesting the alluring possibility that we might someday understand them as a functional collective. Our progress toward that “big picture” goal is ...

Robo keeps axons moving F or migrating axons, attraction becomes repulsion with the fl ip of an alternatively spliced switch, according to Zhe Chen, Marc Tessier-Lavigne (Genentech Inc., San Francisco, CA), and colleagues. A melange of chemoattractants and repellants guides growing axons to their targets. Axons that cross the midline of the spinal cord on their way toward the nascent brain, how...