NAD(P)H: quinone oxidoreductase 1 (NQO1) is an endogenous cellular defence mechanism against several carcinogenic quinones derived from cigarette smoke. NQO1 C609T polymorphism is a strong determinant of NQO1 structure and function. The people with mutant allele for this polymorphism has significantly reduced NQO1 activity. In this study, we tried to evaluate the risk of lung cancer as...

Changes in energy metabolism, substrate use, and hormone profiles were prospectively studied in 31 patients with small cell lung cancer receiving chemotherapy. Patients were randomized to receive either 4 weeks of total parenteral nutrition (n = 15) or to continue self-regulated p.o. diet (control group; n = 16). The initial actual resting energy expenditure measured by indirect calorimetry was...

Changes in energy metabolism, substrate use, and hormone profiles were prospectively studied in 31 patients with small cell lung cancer receiving chemotherapy. Patients were randomized to receive either 4 weeks of total parenteral nutrition (n = 15) or to continue self-regulated p.o. diet (control group; n = 16). The initial actual resting energy expenditure measured by indirect calorimetry was...

Introduction: One of the treatment choices in breast cancer is Intra operative electron beam radiation therapy (IOERT). Due to high dose delivery in this procedure, shielding disk is used to protect organs at risk (OARs). In this study, we evaluate the OARs dose in the breast IOERT using Monte Carlo simulation with and without shielding disk in RANDO phantom. Material and Methods: Simulation ...

Introduction: In the point of physical view, there are no significant differences between tumor and normal tissues during radiation therapy. Radio-sensitizers have a key role to address the issue. Exploiting high atomic number, gold nanoparticles (GNPs) have been introduced as novel radio-sensitizers and have shown promising result in the field. Owing to high mass attenuation c...

oral glutamine supplementation is highly effective in preventing and delaying radiation-induced esophagitis, one of the most common discomforting side effects of radiation to the thoracic area among lung cancer patients. according to the literature, lung cancer is the leading cause of death among all cancers with the highest incidence worldwide. this paper aims to emphasize the importance of or...

background: to determine which radiotherapy parameters are associated with the tumor response of locally advanced non-small cell lung cancer (nsclc) patients undergoing concurrent chemoradiotherapy. materials and methods: thirty one patients with iiia/iiib nsclc underwent chemoradiotherapy with a median dose of 63 gy. on our actual treatments, we made radiotherapy planning to cover the planning...

background: radon is the second leading cause of lung cancer after smoking. in canada, the health authorities have no access to comprehensive profile of the communities built over uranium-rich micro-geological settings. the present indoor radon monitoring guideline is unable to provide an accurate identification of health hazards due to discounting several parameters of housing characteristics....

objective(s):n-myc downstream regulated gene 2 (ndrg2) is a candidate gene for tumor suppression. the expression of ndrg2 is down-regulated in several tumors including lung cancer. the aim of this study was to explore the effect of ndrg2 overexpression on invasion, migration, and enzymatic activity of matrix metalloproteinase-2 (mmp-2) and -9 (mmp-9) in human lung adenocarcinoma a549 cells.  ma...