نتایج جستجو برای: mediated dilation
تعداد نتایج: 420233 فیلتر نتایج به سال:
Altered vitamin D metabolism and low levels of the active form of this vitamin, 1,25-dihydroxy-vitamin D, is a hallmark of chronic kidney disease (CKD), but there is still no randomized controlled trial testing the effect of active forms of vitamin D on vascular function in patients with CKD. Paricalcitol and ENdothelial fuNction in chronic kidneY disease (PENNY) is a double-blinded randomized ...
BACKGROUND Although acute elevation in retrograde shear rate (SR) impairs endothelial function, no previous study has explored the effect of prolonged elevation of retrograde SR on conduit artery vascular function. We examined the effect of 2-weeks elevation of retrograde SR on brachial artery endothelial function in young and in older men. METHODS AND RESULTS Thirteen healthy young (23±2 yea...
the aim of this study was to evaluate the effect of estradiol (e2), oxytocin (ot), relaxin (relaximol) injection and prostaglandin e1 (misoprostol) suppository on the cervix dilation, time of cervical dilation persistency and pregnancy rate of zandi ewes using artificial insemination. eighty 3-4 years old and 55±2.5 kg weight ewes were used for this study. in experiment 1, the ewes were assigne...
BACKGROUND End-stage renal disease is accompanied by functional and structural vascular abnormalities. The objective of this study was to characterize vascular function in a large cohort of patients with end-stage renal disease, using noninvasive physiological measurements, and to correlate function with demographic and clinical factors. METHODS AND RESULTS We analyzed cross-sectional baselin...
BACKGROUND By inhibiting 3-hydroxy-3-methylglutaryl coenzyme A reductase, statins not only reduce cholesterol biosynthesis but also decrease the formation of isoprenoids, which are important for mediating signaling through the Rho-associated coiled-coil containing protein kinase (ROCK) pathway. Increased ROCK activity has been implicated in endothelial dysfunction and vascular inflammation. We ...
We used pharmacological methods to test the hypothesis that female Dermacentor variabilis salivary ducts dilated when dopamine-stimulated and that dilation was nitric oxide-mediated. Stimulation with dopamine resulted in an increased diameter (19.7%) compared to unstimulated ducts (P<0.005). Pretreatment with L-NAME, an inhibitor of nitric oxide synthase, or cytochalasin D abolished the dilatio...
BACKGROUND Alterations in intravascular pressure can affect vascular function and the morphological properties of arteries. Although it has been shown that a transient elevation of blood pressure impairs endothelium-dependent dilation in small arteries, the vascular dilation responses during high intravascular pressure have not yet been investigated. METHODS AND RESULTS Using pressure myograp...
Whether endothelium-derived relaxing factor (EDRF)/nitric oxide (NO) plays a role in the dilation of the left circumflex coronary artery during acute exercise and whether endothelium-mediated dilation of this artery is altered after chronic exercise training have not been determined previously. Nine dogs were chronically instrumented for measurements of systemic hemodynamics, left circumflex co...
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