Cells regularly synthesize new proteins to replace old or damaged proteins. Deposition of various aberrant proteins in specific brain regions leads to neurodegeneration and aging. The cellular protein quality control system develop various defense mechanisms against the accumulation of misfolded and aggregated proteins. The mechanisms underlying the selective recognition of specific crucial pro...

Biological aging is characterized by a progressive accumulation of oxidative damage and decreased endogenous antioxidant defense mechanisms. The production of oxidants by normal metabolism damages proteins, lipids, and nucleotides, which may contribute to cognitive impairment. In this study 36 dogs were randomly divided into four groups and fed croquettes of different compositions for 6 months....

Plants exist in a world filled with microorganism. They continue to grow in the same location throughout the growing season or for many years, as in the case of perennial plants. Their surfaces are constantly exposed to bacteria, fungi, nematodes, and possibly parasitic plants. They may be inoculated with viruses during feeding by insects or by other vectors. Plant pathogens have made many adap...

This paper proposes a study of distributed denial-of service attacks and a study of the defense mechanism that strive to counter these attacks. The attack illustrate do using both known and potential attack mechanisms along with this classification we discuss important feature .So each attack category that in turn define the challenge involved in combating these threats. Distributed Denial of S...

OBJECTIVE Current understanding of the use of psychological defense mechanisms (DMs) in older adults is limited. This study set out to examine individual differences in DMs and Cloninger's biosocial model of personality in two age groups (50-64, 65-93), as well as their influence on health. METHODS A Japanese community sample (N = 330) completed the Temperament and Character Inventory (TCI-12...

Although adequate self-esteem is essential for psychological health, people with high but fragile self-esteem have been shown to exhibit defensive, often aggressive behavior when their self-esteem is threatened. We measured physician narcissism (as a proxy for high but fragile self-esteem) and used a subtle manipulation to examine how physicians who varied in levels of narcissism responded to a...

Proponents of Terror Management Theory (TMT) argue that many facets of disgust serve to defend against existential anxiety accompanying cognizance of one’s mortality. Because the passage of time brings death closer, this view predicts that the intensity of disgust elicited by reminders of death should increase with age. Skeptical of TMT, we conducted Internet-based studies using the instrument ...

Fusarium wilt caused by Fusarium oxysporum f. sp. pisi (Fop) is one of the most destructive diseases of pea worldwide. Control of this disease is difficult and it is mainly based on the use of resistant cultivars. While monogenic resistance has been successfully used in the field, it is at risk of breakdown by the constant evolution of the pathogen. New sources of quantitative resistance have b...

As a highly reactive substance produced in biological systems by the one-electron reduction of oxygen, superoxide (O(2) (-)) seemed a likely candidate as a bactericidal agent in leukocytes. The reduction of cytochrome c, a process in which O(2) (-) may serve as an electron donor, was found to occur when the cytochrome was incubated with leukocytes. O(2) (-) was identified as the agent responsib...