UNLABELLED A modified vaccinia virus Ankara poxvirus vector expressing the HIV-1 Env, Gag, Pol, and Nef antigens from clade B (MVA-B) is currently being tested in clinical trials. To improve its immunogenicity, we have generated and characterized the immune profile of MVA-B containing a deletion of the vaccinia viral gene N2L, which codes for an inhibitor of IRF3 (MVA-B ΔN2L). Deletion of N2L h...

The potential use of the modified vaccinia virus Ankara (MVA) strain as a live recombinant vector to deliver antigens and elicit protective immune responses against infectious diseases demands a comprehensive understanding of the effect of MVA infection on human host gene expression. We used microarrays containing more than 15,000 human cDNAs to identify gene expression changes in human HeLa ce...

Live recombinants based on attenuated modified vaccinia virus Ankara (MVA) are potential vaccine candidates against a broad spectrum of diseases and tumors. To better understand the efficacy of MVA as a human vaccine, we analyzed by confocal and electron microscopy approaches MVA-induced morphological changes and morphogenetic stages during infection of human HeLa cells in comparison to other s...

INTRODUCTION THERE has been a trend in recent years toward larger capacity turbine generators. Larger output systems draw worldwide interest, and from the standpoint of efficient use of resources, expectations are particularly focused on large-capacity 2-pole generators for coalfired power plants. Hitachi has been in the forefront of efforts to develop better large-output 2-pole generators to m...

Objective: Although many studies in medical literature are comparing percutaneous trans-septal mitral commissurotomy (PTMC) and open mitral commissurotomy (OMC), very few long-term comparative follow-ups are available. Methods: Between January 1991 and December 1997, 193 patients with isolated mitral stenosis were assigned either to PTMC (111 cases) or to OMC (82 cases). PTMC was performed in a...

Abstract Aims Although the importance of microvascular angina (MVA) has been emerging, prognostic biomarkers for MVA remain to be developed. We thus aimed examine whether plasma level N-terminal prohormone brain natriuretic peptide (NT-pro BNP) could predict prognosis patients. Methods In international prospective cohort study patients by Coronary Vasomotor Disorders International Study (COVADI...

Bernstein polynomials are a classical tool in Computer Aided Design to create smooth maps with a high degree of local control. They are used for the construction of Bézier surfaces, free-form deformations, and many other applications. However, classical Bernstein polynomials are only defined for simplices and parallelepipeds. These can in general not directly capture the shape of arbitrary obje...

In this article, we will discuss various issues concerning when a complete Riemannian manifold possesses a global mean value inequality for positive subsolutions of either the Laplace equation or the heat equation. This study is motivated by the recent result of the first author [L1]. In that paper, he proved estimates on the dimensions of spaces of harmonic functions of at most polynomial grow...