We examined the extent to which the intracellular polymerization of sickle hemoglobin (HbS) can account for the severity of anemia and of vaso-occlusive manifestations in the various sickling syndromes. Polymer formation in sickle cell disease depends principally on the intraerythrocytic hemoglobin composition and concentration. In our studies, the polymer fraction in sickle red cells was deter...

No previous study has investigated the full range of complete blood count (CBC) parameters in small-for-gestational-age (SGA) newborns. The main aim of this study was to compare CBC and peripheral smear parameters in term, healthy SGA neonates and appropriate-for-gestational-age (AGA) neonates, and to establish CBC reference values for full-term SGA newborns. One hundred thirty-two healthy, ter...

BACKGROUND Epidemiological and clinical studies in high income countries have suggested that Helicobacter pylori (H. pylori) may cause anaemia, but evidence is lacking from low income countries.We examined associations between H. pylori infection in early childhood and anaemia at the age of 6.5 years in an Ethiopian birth cohort. METHODS In 2011/12, 856 children (85.1 % of the 1006 original s...

Cancer is a cellular change caused by uncontrolled cell growth and division. This disease develops from the of abnormal cells that have potential to invade or spread other parts body. The aim this study was investigate relationship between blood parameters (e.g., Mean corpuscular volume (MCV), hemoglobin (MCH), Corpuscular Hemoglobin Concentration (MCHC), Haemoglobin (HGB), White Blood Cell (WB...

Hydroxyurea (HU), an inhibitor of DNA synthesis, has been shown to increase fetal hemoglobin (HbF) levels in patients with sickle cell anemia and in some patients with beta-thalassemia. However, until now there have not been good in vitro model systems that simulate this effect for study of the molecular and cellular mechanism(s) involved in perturbing the normal ontogeny of the globin genes. W...

BACKGROUND During its intraerythrocytic asexual reproduction cycle Plasmodium falciparum consumes up to 80% of the host cell hemoglobin, in large excess over its metabolic needs. A model of the homeostasis of falciparum-infected red blood cells suggested an explanation based on the need to reduce the colloid-osmotic pressure within the host cell to prevent its premature lysis. Critical for this...

AIM To investigate the association between obesity and anemia/hemoglobin levels. MATERIAL & METHODS A cross-sectional study was conducted at Khartoum, Sudan. Obstetric data were collected from 388 pregnant women at mean (standard deviation) of 10.5 (3.1) weeks of gestation using questionnaires. Weight and height were determined, and BMI was calculated. RESULTS There were 15 (4.4%), 95 (28.1...

Objective: To study the pattern of hematological parameters in Type 2 diabetic patients. Study Design: Observational Cross Sectional. Setting: Creek General Hospital, Karachi. Period: June to December 2021. Material & Methods: Two hundred and five patients were selected by convenient sampling technique. Inclusion Criteria was individuals more than 30 years old, diagnosed with DM greater 3 m...

To diagnose acute myocardial infarction, selected cardiac markers as well as hematological and biochemical indices have been studied in human being, however, rare investigations were done on the values of hematologic analysis in an ovine model of myocardial infarction. To observe the change of the values in hematologic parameters in sheep, acute myocardial infarction was induced by ligation of ...