BACKGROUND Multidrug-resistant (MDR) infections are a serious concern for children admitted to the Paediatric Intensive Care Unit (PICU). Tracheal colonization with MDR Enterobacteriaceae predisposes to respiratory infection, but underlying risk factors are poorly understood. This study aims to determine the incidence of children with suspected infection during mechanical ventilation and analys...

Phenothiazines have their primary effects on the plasma membrane of prokaryotes and eukaryotes. Among the components of the prokaryotic plasma membrane affected are efflux pumps, their energy sources, energy providing enzymes such as ATPases, and genes that regulate and code for permeability aspects of the bacterium. The responses of multi-drug (MDR) and extensively drug resistant (XDR) Mycobac...

TOPIC: Chest Infections TYPE: Original Investigations PURPOSE: Pseudomonas aeruginosa is a common pathogen, causing chronic and life-threatening infections in airways of patients with cystic fibrosis (CF). Multidrug-resistant P.aeruginosa (MDR-PA), an important cause persistent due to its ability form biofilms which display tolerance high resistance antimicrobial agents Traditional antibiotic s...

Multidrug-resistant (MDR) Klebsiella pneumoniae is increasing worldwide with poorly characterised epidemiology in many parts of the world, particularly Africa. This study aimed to investigate molecular K. pneumoniae, identify diversity sequence types (ST), and detect carbapenem resistance genes major regional hospitals Khartoum, Sudan. isolates (n = 117) were cultured from four April 2015 Octob...

Antimicrobial resistance has emerged as a major global concern for public health in the last two decades, which tends to compromise existing drug regimens treating common or severe infections. According WHO, three million laboratory-confirmed bacterial infections have been reported from 70 countries 2019, caused by pathogens of concern. The drug-resistant strains are characterized multidrug-res...

In this project, we employed ethanolic (EMI) and aqueous (AMI) extracts of mango (Mangifera indica L., Anacardiaceae) fruit seeds as a modulator antibiotic resistance against multidrug-resistant (MDR) Pseudomonas aeruginosa Acinetobacter baumannii to evaluate natural compounds isolated from by-products or waste edible plants. We also investigated the effect these alone in combination with stand...

BACKGROUND Better depicting the relationship between antibiotic consumption and evolutionary healthcare-associated infections (HAIs) caused by multidrug-resistant Gram-negative bacilli (MDR-GNB) may help highlight the importance of antibiotic stewardship. METHODOLOGY/PRINCIPAL FINDINGS The correlations between antibiotic consumption and MDR-GNB HAIs at a 2,700-bed primary care and tertiary re...

conclusions the result of the current study showed the growing number of nosocomial infections associated with xdr a. baumannii causing difficulties in antibiotic therapy. resistant strains increasingly cause public health problems; therefore, their early detection is essential for healthcare centers. results among the 121 isolated a. baumannii, 44% and 56% were isolated from female and male, r...

Infections caused by multidrug resistant (MDR) bacteria are a major concern worldwide. Changes in membrane permeability, including decreased influx and/or increased efflux of antibiotics, are known as key contributors of bacterial MDR. Therefore, it is of critical importance to understand molecular mechanisms that link membrane permeability to MDR in order to design new antimicrobial strategies...