Background. Some observational studies have suggested that excess dietary intake of polyunsaturated fatty acids such as linoleic acid increases cutaneous melanoma risk. We aimed at examining the association between serum fatty acids and melanoma risk by conducting a population-based case-control study in a northern Italy community. Methods. The percentage composition of 12 fatty acids was deter...

We have recently shown that saturated, monounsaturated and polyunsaturated fatty acids, including those of fish-oil origin, inhibit [ 'Hlthymidine incorporation into DNA of concanavalin A (Con A)-stimulated rat lymph node lymphocytes [ 1, 21. All nine fatty acids tested inhibited the response to mitogen, but the extent of inhibition was dependent upon the fatty acid concentration used, the time...

Dietary fats have important effects on the risk of cardiovascular disease (CVD). Abundant evidence shows that partial replacement of saturated fatty acids (SAFA) with unsaturated fatty acids improves the blood lipid and lipoprotein profile and reduces the risk of coronary heart disease (CHD). Low-fat diets high in refined carbohydrates and sugar are not effective. Very long-chain polyunsaturate...

Accumulation of lipids in nonadipose tissues can lead to cell dysfunction and cell death, a phenomenon known as lipotoxicity. However, the signaling pathways and mechanisms linking lipid accumulation to cell death are poorly understood. The present study examined the hypothesis that saturated fatty acids disrupt endoplasmic reticulum (ER) homeostasis and promote apoptosis in liver cells via acc...

Qinghai Plateau yak are the most important grazing livestock for milk and beef production on the Qinghai-Tibetan plateau because they are adapted to extremes of cold environment and higher elevation and can be grazed throughout the year. Milk samples (n = 47) from Qinghai Plateau yak cows of different parities and milk samples (n = 6) from Qinghai yellow cattle cows were analyzed using gas chro...

BACKGROUND Saturated fatty acids are thought to be of relevance for the development of non-alcoholic fatty liver disease and obesity. However, the underlying mechanisms are poorly understood. In previous studies we found that food-derived carbohydrates such as fructose alter the intestinal serotonergic system while inducing fatty liver disease in mice. Here, we examined the effect of fatty acid...

The effectiveness of increasing CLA in pork products through animal dietary supplementation or direct addition in the product formulation has been studied, and the effect of grilling on dry matter and fat contents and fatty acid composition has been analysed. Sausages made with meat and back fat from pigs with CLA dietary supplementation had the highest saturated fatty acid content. Sausages fr...

The presence of food within the small intestinal lumen promotes mucosal cell proliferation. To define the trophic role of triglycerides, three groups of eight female Wistar rats were isocalorically fed for four weeks with either Vivonex, or Vivonex with 50% calorie substitution with an essential fatty acid mixture, or Vivonex with 50% calorie substitution with a saturated fatty acid mixture. Al...

OBJECTIVE We examined cross-sectional associations of total, hydrogenated, and natural trans fatty acid intake with selected metabolic risk factors in young Japanese women. METHODS Subjects were 1136 Japanese female dietetic students aged 18-22 years. Dietary intake was estimated using a validated, self-administered diet history questionnaire. Associations between trans fatty acid intake and ...