BACKGROUND Next-Generation Sequencing (NGS) has made genomic mutation-driven therapy feasible for metastatic breast cancer (MBC) patients. We frequently submit tumor tissue from MBC patients for targeted NGS of tumor using the Illumina HiSeq 2000 platform (FoundationOne®, Foundation Medicine, MA). Herein, we report the results and clinical impact of this test in MBC patients. PATIENTS AND MET...

BACKGROUND Male breast cancer (MBC) is a rare disease that accounts for less than 1% of all cancers in men and less than 1% of all diagnosed breast cancers. In this study, we retrospectively evaluated the clinicopathological features, treatment options and overall survival in Kurdish MBC cases. MATERIALS AND METHODS Seventeen MBC were referred to Department of Radiation Oncology in Imam Reza ...

BACKGROUND Circulating tumor cells (CTCs) are associated with inferior prognosis in metastatic breast cancer (MBC). We hypothesized that the relationship between CTCs and disease subtype would provide a better understanding of the clinical and biologic behavior of MBC. PATIENTS AND METHODS We retrospectively analyzed 517 MBC patients treated at a single institution. Subtypes of primary tumors...

The fact that the results for 2-receiver broadcast channels (BCs) are not generalized to the 3-receiver ones is of information theoretical importance. In this paper we study two classes of discrete memoryless BCs with non-causal side information (SI), i.e. multilevel BC (MBC) and 3-receiver less noisy BC. First, we obtain an achievable rate region and a capacity outer bound for the MBC. Second,...

AIMS--To evaluate the immunoreactivities of neoplastic and non-neoplastic monocytoid B cells (MBC) and compare them with hairy cell leukemia (HCL) and mantle cell lymphoma (MCL). METHODS--An immunohistochemical study of paraffin wax embedded sections was done on surgically resected specimens of spleens with MBC clusters from patients with gastric cancer (14 cases), tonsils (five cases), and lym...

BACKGROUND Untreated postoperative urinary retention can result in permanent lower urinary tract dysfunction and can be prevented by timely bladder catheterization. The author hypothesized that the incidence of postoperative bladder catheterization can be decreased by using the patient's own maximum bladder capacity (MBC) instead of a fixed bladder volume of 500 ml as a threshold for catheteriz...

Background: Platinum complexes are active in a wide range of solid tumors. Although both cisplatin and carboplatin have shown activity in breast cancer. However, some recent reports have demonstrated encouraging results, especially carboplatin in combination with taxanes. Aims: To evaluate efficacy and safety of the combination of Craboplatin (C) and weekly paclitaxel (P) as first line therapy ...

BACKGROUND Taxanes are an established treatment of metastatic breast cancer (mBC). Biological therapies that can be effectively combined with taxanes may provide an alternative to taxane-chemotherapy doublets, which are not suitable for all patients. PATIENTS AND METHODS Bevacizumab is a humanised mAb against vascular endothelial growth factor (VEGF) which inhibits angiogenesis. This review s...