Platelet preparations promote bone regeneration by inducing cell migration, proliferation and differentiation in the area of the injury, which are essential processes for regeneration. In addition, several studies have indicated that simvastatin (SIMV), widely used for the treatment of hypercholesterolemia, stimulates osteogenesis. The objective of this study was to evaluate the effects of trea...

Oleanolic acid (OA) is a triterpenoid with reported bone anti-resorption activities. The present study aimed to characterize its bone protective effects in vivo and to study its effects on vitamin D metabolism, both in vivo and in vitro. OA significantly increased bone mineral density, improved micro-architectural properties, reduced urinary Ca excretion, increased 1,25(OH)₂D₃ and renal CYP27B1...

Weights of Polled Hereford and ‘Wokalup’ cows in the Wokalup selection experiment were obtained monthly, with up to 11 years of records per cow available. Mature weights were analysed treating them as repeated records per animal and by fitting a Gompertz growth curve for each animal. Estimates of heritabilities for mature weight were 0.3 to 0.4 for Herefords and 0.5 to 0.6 for Wokalups, and 0.3...

Rapid palatal expansion has been associated with significant short and long term unwanted effects such as dentoalveolar tipping detrimental periodontal when carried out in skeletally mature individuals. Mini implant assisted rapid (MARPE) proven to reduce the undesirable seen tooth supported expanders allows even adults. A variety of designs have suggested their pros cons. Biomechanically, it i...

HE PRODUCTION of neutrophil granulocytes is a T complex and dynamic process during which a small number of self-renewing stem cells give rise to lineagespecific progenitors that proliferate and mature in the bone marrow, subsequently entering the blood as mature polymorphonuclear leukocytes. One hematopoietic glycoprotein that appears to specifically control the survival, cycle activation, prol...

Although porous-surfaced orthopedic implants have been designed for fixation by bone ingrowth, there is clinical evidence that this does not always occur. Initial implant movement relative to host bone can result in attachment by a non-mineralized fibrous connective tissue layer. The ranges of movement that result in either bone or fibrous connective tissue fixation are observed in dogs in two ...

Specialized adaptations for application of Goldner's Masson trichrome stain to plastic embedded undecalcified bone specimens are presented. This stain can be used successfully on methyl-glycol methacrylate, glycol methacrylate and Spurr embedded bones. The stain affords the advantage of good cellular staining due to the hematoxylin component with concomitant sharp discrimination of mature bone ...

Objective(s): Design and construction of biocompatible and biodegradable scaffolds are among the main goals of tissue engineering. Recently, use of nano-hydroxyapatite as a bioactive bioceramic agent with high similarity to the mineral phase of the human bone tissue, in combination with biodegradable polymers and implant coatings has attracted the attention of researchers in the field of biomat...

Antibodies and B cells are critical in the protective immune response to the blood stage of the malaria parasite, Plasmodium chabaudi. However, little is known about the development of memory B cells and their differentiation into plasma cells during infection or after re-infection. Here we have shown that B cells with phenotypic characteristics of memory cells (CD19(+)IgD(-) CD38(+), IgG1(+)) ...