OBJECTIVE To compare cord blood leptin concentrations between normal pregnancy, pregnancy induced hypertension (PIH), and gestational diabetes mellitus (GDM). DESIGN Cross-sectional study. SETTING Academic institutes and a tertiary care maternal hospital. METHOD 48 newborns of normal pregnancies (N=18), pregnancy induced hypertension (N=16), and gestational diabetes mellitus (N=14) were s...

BACKGROUND Metabolic and endocrine environment during early life is crucial for metabolic imprinting. When dams were fed a high fat diet (HF diet), rat offspring developed hypothalamic leptin resistance with lean phenotype when weaned on a normal diet. Interestingly, when grown on the HF diet, they appeared to be protected against the effects of HF diet as compared to offspring of normally fed ...

Bisphenol A (BPA) is a high volume production chemical that has been detected in 93% of the United States population. It is thought to have endocrine disrupting activity but human data are limited. In this study, we examined whether prenatal or concurrent urinary BPA concentrations are associated with key metabolism-related hormones, adiponectin and leptin (adipokines), in 9-year-old children. ...

Recent studies have demonstrated that epigenetic changes resulting from malnutrition might play important roles in transgenerational links with metabolic diseases. Previously, we observed that exposure to a high-fat diet (HFD) in utero caused a metabolic syndrome-like phenomenon through epigenetic modifications of the adiponectin and leptin genes that persisted for multiple generations. Recent ...

We tested the hypothesis that maternal supply of essential fatty acids (EFA), especially ?-linolenic acid, and conjugated linoleic acid (CLA), affects glucose metabolism, endocrine regulation energy metabolism growth, intestinal development neonatal calves. studied calves from dams received an abomasal infusion 76 g/d coconut oil (CTRL; n = 9), 78 linseed 4 safflower (EFA; 38 Lutalin (BASF SE) ...

Objective. Leptin is a highly hydrophilic protein that circulates in plasma as a 16-kDa protein. It is produced in adipose tissue and also recently described to be synthesized by placental tissue. Plasma concentration of leptin is positively correlated to body fat mass, and administration of recombinant leptin to mice indicates that leptin participates in the regulation of food intake and energ...

The prognostic characteristics of pancreatic cancer (PC) are determined by the contributing factors from tumor microenvironment. Leptin is a critical oncogenic factor released adipocytes as an adipokine into microenvironment, where it promotes development activating stem cell (CSC) molecular regulators Notch, Hedgehog, and Wnt/ß-catenin signaling. One downstream targets these pathways CDK4/6 cy...

Propose: Maternal diabetes, nausea, changes in appetite, blood pressure alteration, anxiety, complication of fetus growth and many other obstacles that happen during pregnancy are related to the changes of circulating hormones. To illuminate the reasons for some of these problems, present work was designed. Method: Seventy-seven healthy women aged 22-30 years (Pregnant, n=43, gestational age be...

OBJECTIVE Offspring of mothers with type 1 diabetes (OT1DM) demonstrate increased fat deposition, hyperinsulinemia, and hyperleptinemia in utero. We examined the influence of maternal diabetes on cord lipids at birth and relationship to body composition, cord insulin, leptin, and other hormonal measures. RESEARCH DESIGN AND METHODS We performed an observational study measuring fetal, HDL, and...

BACKGROUND Breastfeeding may protect children from developing metabolic syndrome and other diseases later in life. We investigated novel proteins in human breast milk that might play a role in this process. METHODS We used ELISA to measure adiponectin, adipocyte and epidermal fatty acid binding proteins (AFABP, EFABP), and leptin concentrations in human breast milk obtained from 59 mothers 48...