Evolutionary pressures have probably amplified the mechanisms for minimizing the impact of environmental factors through compensatory maternal mechanisms. Nevertheless, experimentally there are clear long-term programming effects of manipulations to the maternal diet on the likelihood of neural-tube defects associated with folate deficiency The fat/lean ratios of the newborn, and subsequent dev...

The objective of this project was to determine if the placental weight/ratio is affected by various maternal variables such as maternal age, BMI, gestational diabetes, and race using various mathematical approaches. A study was performed on 1229 mothers who were of different age groups, five different races, various BMI, and approximately 4% had gestational diabetes. We analyzed each of these f...

Maternal diabetes is known to adversely influence brain development in offspring. Here, we provide evidence that this involves the circulating metabolite methylglyoxal, which is increased in diabetes, and its detoxifying enzyme, glyoxalase 1 (Glo1), which when mutated is associated with neurodevelopmental disorders. Specifically, when Glo1 levels were decreased in embryonic mouse cortical neura...

AIM To describe the clinical profile, maternal and fetal outcomes, and the conversion rates to diabetes in women with gestational diabetes mellitus (GDM) seen at a tertiary care diabetes center in urban south India. MATERIALS AND METHODS Clinical case records of 898 women with GDM seen between 1991 and 2011 were extracted from the Diabetes Electronic Medical Records (DEMR) of a tertiary care ...

Background: Gestational diabetes is one of the common causes of maternal and fetal complications. Due to fetal and maternal complications of diabetes, it is very important to reduce the prevalence of diabetes and its consequences. The relationship between vitamin D deficiency and type 2 diabetes has been reported. There is little information about the relationship between serum vitamin D levels...

Background: Many factors affect exclusive breastfeeding, include method of delivery, parity, maternal age and education, smoking, ethnicity, pregnancy complications, infant health, and environmental factors such as hospital practices, and social support. Recently, maternal obesity has been suggested as a risk factor for poor breast-feeding practices whose role has not...

Background: External genital anomalies are the most common congenital disorders in male infants with unknown etiology in the majority of cases. According to recent reports, incidence rate of these anomalies is rising in different countries. This study aimed to evaluate the prevalence of external genital anomalies and possible underlying factors in male newborns. Methods: This cross-sectional st...

AIMS Telomeres undergo shortening with cell division, accelerated by increased oxidative stress. We aimed to demonstrate shortened telomeres in the offspring of mothers who have diabetes as a consequence of exposure to increased oxidative stress during intrauterine development. METHODS We examined the level of glycaemia (glucose, HbA1c, fructosamine), oxidative stress (lipid peroxidation) and...

OBJECTIVE The objective of the study was to determine the association between child BMI at age 3 years and maternal glucose concentration among women without pre-existing diabetes or a gestational diabetes mellitus (GDM) diagnosis. RESEARCH DESIGN AND METHODS Data are from the Pregnancy Infection and Nutrition and Postpartum studies and include 263 mother-child pairs. Measured weights and hei...

Objective: Untreated gestational diabetes mellitus (GDM) may lead to increased risk of macrosomia, congenital anomalies, unexplained stillbirth, hypoglycemia and jaundice in newborns. This prospective study was conducted to evaluate feto-maternal outcome in women with GDM. Materials and Methods: Two hundred pregnant women underwent 75grams glucose challenge test according to Diabetes in Pregna...