BACKGROUND Mating-type loci in yeasts and ascomycotan filamentous fungi (Pezizomycotina) encode master transcriptional factors that play a critical role in sexual development. Genome-wide analyses of mating-type-specification circuits and mating-type target genes are available in Saccharomyces cerevisiae and Schizosaccharomyces pombe; however, no such analyses have been performed in heterothall...

BACKGROUND Medication-assisted treatment (MAT) remains the gold standard for the treatment of opioid use disorder. MAT also reduces the frequency of injecting among people who inject drugs (PWID). Relatedly, data suggest that PWID play a key role in the initiation of others into drug injecting by exposing injecting practices to injection-naïve drug users. Our primary objective was to test wheth...

INTRODUCTION Landing mats that undergo large area deformation are now essential for the safe completion of landings in gymnastics. The aim of this study was to determine the effective mass, shock transmission time, and deformation characteristics of a mat during impacts using high-speed video and to improve the accuracy of measuring foot-mat contact forces during landing. For validation, the sa...

Mating in basidiomycetous fungi is often controlled by two unlinked, multiallelic loci encoding homeodomain transcription factors or pheromones/pheromone receptors. In contrast to this tetrapolar organization, Cryptococcus neoformans/Cryptococcus gattii have a bipolar mating system, and a single biallelic locus governs sexual reproduction. The C. neoformans MAT locus is unusually large (>100 kb...

BACKGROUND We observed that some patients with clinical leptospirosis supported by positive results of rapid tests were negative for leptospirosis on the basis of our diagnostic gold standard, which involves isolation of Leptospira species from blood culture and/or a positive result of a microscopic agglutination test (MAT). We hypothesized that our reference standard was imperfect and used sta...

The Guerrero Negro (GN) hypersaline microbial mats have become one focus for biogeochemical studies of stratified ecosystems. The GN mats are found beneath several of a series of ponds of increasing salinity that make up a solar saltern fed from Pacific Ocean water pumped from the Laguna Ojo de Liebre near GN, Baja California Sur, Mexico. Molecular surveys of the laminated photosynthetic microb...

Methionine adenosyltransferases MAT I and MAT III (encoded by Mat1a) catalyze S-adenosylmethionine synthesis in normal liver. Major hepatic diseases concur with reduced levels of this essential methyl donor, which are primarily due to an expression switch from Mat1a towards Mat2a. Additional changes in the association state and even in subcellular localization of these isoenzymes are also detec...

This paper discusses an innovative approach to knowledge based Machine Aided Translation (MAT) where the translator is supported by an user-friendly environment providing linguistic and domain knowledge explanations. Our project aims at integration of a Knowledge Base (KB) in a MAT system and studies the integration principles as well as the internal interface between language and knowledge. Th...

To investigate the extent of genetic stratification in structured microbial communities, we compared the metagenomes of 10 successive layers of a phylogenetically complex hypersaline mat from Guerrero Negro, Mexico. We found pronounced millimeter-scale genetic gradients that were consistent with the physicochemical profile of the mat. Despite these gradients, all layers displayed near-identical...

4. Let (Ω,Σ, μ) be a measure space. If f : Ω → R, then we say that f is a measurable function if for every t ∈ R, the level set: Sf (t) = {x ∈ Ω|f(x) > t} is measurable. f : Ω→ C is measurable if and only if both Re(f) and Im(f) are measurable. 5. A real function f : Ω → R is lower semicontinuous on Ω if Sf (t) is open, and is upper semicontinuous if {x ∈ Ω|f(x) < t} is open. Equivalently, f is...