familial hypercholesterolemia (fh) is an inherited common autosomal mendelian disorder of lipoprotein metabolism with a population prevalence of 1 in 500. fh is characterized by severely elevated levels of low-density lipoprotein cholesterol (ldl-c), which result in surplus deposition of cholesterol in tissues. this condition leads to premature at hero sclerosis and early-onset of coronary hear...

child abuse is a critical and extensive problem. each year, in the united states, almost more than a million children are abused, and related injuries are accounted for 2,000 to 5,000 children deaths. physicians are in an excellent and legal position to identify and report cases of child abuse and neglect. this guideline was provided to help general practitioners to identify and direct the diff...

introduction: colorectal cancer is the most common cancer of the alimentary system. in women, it is the second leading cause of mortality after breast cancer while in men, it is the third leading cause of death after lung and prostate carcinoma. prevalence is more in population older than 50 years and increases in older people. therefore, best treatment and prognosis is early diagnosis of disea...

with an occurrence of 7%, appendicitis is one of the most common abdominal emergencies requiring surgery. since the variation in positions and length of the appendix may produce varying symptoms and signs which mimic other diseases, having knowledge of the variations in the position of the appendix is of significant importance. here, we present a 77-year-old man with acute appendicitis presenti...

background: alveolar echinococcosis (ae) is a chronic, rare and sometimes lethal parasitic infection in humans, caused by the larval stage of the fox tapeworm echinococcus multilocularis. this study aimed to investigate the clinical aspects and treatment outcomes of patients with alveolar hydatid disease. methods: the medical records of patients with alveolar echinococcosis admitted between 199...

background: in many cases of ild (interstitial lung disease), overlap diagnosis is considered. here, a few cases with diagnosis of a variety of ilds, where eventual open lung biopsy has been performed are selected. reference will be made to reliable sources to show that nsip can still be a variant of uip (usual interstitial pneumonia) with better treatment response and prognosis. case presentat...

abstract background: autosomal dominant polycystic kidney disease (adpkd) is an inherited disorder with genetic heterogeneity. up to three loci are involved in this disease, pkdi on chromosome 16p13.3, pkd2 on 4q21, and a third locus of unknown location. methods: here we report the first molecular genetic study of adpkd and the existence oflocus heterogeneity for adpkd in the iranian population...

conclusions while bdg assay seems to be a sensitive and specific adjunctive tool to diagnose and monitor the experimental systemic candidiasis, it seems that measuring the positive cutoff value in different laboratory conditions is necessary for favorable establishment of these tests. results all the infected rats were positive with bdg tests. an increasing level of bdg was observed during earl...

with significant improve in health-care and treatment of infectious diseases, genetic disorders have created a new era of notification. changes in social attitude towards family life and tendency of parents for limited number of children, sense of responsibility of parents for mental and physical healthiness of children along with their education, needed a new strategy. since most genetic disor...

the importance of nanotechnology in medical technologies, especially biomedical diagnostics, is indubitable. by taking advantages of nanomaterials, many medical diagnostics methods have been developed so far, including electrochemical nanobiosensors. they have been used for quantification of different clinical biomarkers for detecting, screening, or follow up a disease. micrornas (mirnas) are o...