This paper examines the impact of competition from Chinese imports on innovation by U.S. public manufacturing firms. Exploiting cross-industry and over-time trade variations from 1991 to 2004, I find that when Chinese imports surged into the U.S. market, U.S. public manufacturing firms increased their number of patents as a response. In addition, U.S. public manufacturing firms appeared to adop...

Anti-von Willebrand factor (vWF) monoclonal antibody NMC-4 completely inhibited vWF binding to platelet glycoprotein (GP) lb induced by either ristocetin or botrocetin at an IgG concentration of approximately 10 micrograms/mL, and also blocked binding of asialo-vWF to GP lb. NMC-4 coupled beads isolated a 97-Kd fragment (Fr) from a whole tryptic digest of vWF. The N-terminal sequencing of the n...

That information surprises result in discontinuous interest rates is no surprise to participants in the bond markets. We develop a class of jump-di®usion models of the short rate to capture surprise e®ects, and show that these models o®er a good statistical distribution of short rate behavior, and are useful in understanding many empirical phenomena. Continuous-time and discrete-time estimators...

The transition of normally quiescent glomerular MCs (mesangial cells) to a highly proliferative phenotype with characteristics of myofibroblasts is a process commonly observed in inflammatory diseases affecting the renal glomerulus, the ultimate result of which is glomerulosclerosis. Generation of proteolytically active MMP (matrix metalloproteinase)-2 by the membrane-associated membrane type 1...

Presenilin (PSEN) 1 and 2 are the catalytic components of the Gamma-secretase complex, which cleaves a variety of proteins, including the amyloid precursor protein (APP). Proteolysis of APP leads to the formation of the APP intracellular domain (AICD) and amyloid Beta that is crucially involved in the pathogenesis of Alzheimer’s disease. Prolyl-4-hydroxylase-domain (PHD) proteins regulate the h...

Experiments were performed to quantitatively characterize the differential migratory response of human keratinocytes to the polypeptide growth factors EGF and TGF-a. Videomicroscopic tracking of single cells, on collagen IV surfaces, was used to examine the migratory response of cells to a range of growth factor concentrations, as well as to the EGF receptor blocking antibody 225. Results indic...

BACKGROUND Trigger wrist is a rare condition first described by Marti in 1960, and various causes have been reported. The condition mostly occurs with finger flexion and extension, and rarely with flexion and extension of the wrist itself. Avascular necrosis of the capitate is also a rare condition, first described by Jönsson in 1942. While some reports of this condition have been published, li...

The appearance of gynecomastia and other feminizing symptoms in the male concomitant with the appearance of certain types of testicular tumors has long been noted (1). Therefore, the possibility has been suggested that these tumors produce excessive amounts of female sex hormones. The recent work of Goldzieher and Roberts (2) demonstrated that human testes contain small amounts (5.7 y per kilo ...