OBJECTIVE To analyze the relation between vitamin D insufficiency and wound healing in patients with venous ulcers; to correlate vitamin D insufficiency with characteristics of the ulcer (size and pain) and to evaluate if reposition of vitamin D in these subjects expedites ulcer healing. METHODS We selected 26 patients with leg ulcers, and 26 control patients without ulcers, matched for gende...

Quality of ulcer healing (QOUH) is defined as ideal ulcer healing featuring with the fine granular ulcer scar, high functional restoration and the resistance to recurrence. This study was designed to compare the rates of QOUH achievement in rat gastric ulcer model between acid suppressant treated group and gastroprotectant treated group accompanied with elucidations of molecular mechanisms. Ser...

background: basic fibroblast growth factor (bfgf) is a glycoprotein with stimulating ability of angiogenesis. in addition, bfgf plays an important role in wound healing process in some tissues for example gastrointestinal tract, but its ability for discrimination of various stages of wound severity in these diseases was not reported. therefore, we aimed to determine the bfgf levels in gastric u...

Gastric metaplasia is one of the factors in duodenal ulcer appearance. The aim of this study was to investigate the frequency of gastric metaplasia and its connection with age, sex, cigarette smoking and H. pylori infection. In the study 216 patients were included. There were 98 patients with duodenal ulcer, 60 with duodenitis, and 58 healthy control subjects. There was no statistically signifi...

Daemia extensa is a well-known traditional plant in India. The plant is having laxative, anthelmintic, astringent, Immunosuppressive, potent antioxidant, in-vitro antibacterial and antifungal activity. The aim was to search for anti-ulcer activity of ethanolic extract of Daemia extensa seed. Ethanolic extract of Daemia extensa seed was considered for its potential to protect gastric mucosa agai...

BACKGROUND Increased pressure ulcer prevalence and incidence rates led to the development of a pressure ulcer prevention program. OBJECTIVES To decrease pressure ulcer rates below national levels by implementing strategies to improve patient outcomes. METHODS Patients admitted to the Stony Brook University Medical Center (SBUMC) are assessed for placement in the pressure ulcer prevention pr...

We aimed to study the effect of Ramadan fasting on the occurrence of peptic ulcer disease and its complications in patients presenting to the Accident and Emergency Department at Al-Ain hospital, United Arab Emirates (UAE). We retrospectively reviewed patient records over the 10-year period, 1992 to 2002. Of 470 patients treated for peptic ulcer disease, 215 were seen during Ramadan and 255 in ...

Synthesis of prostaglandins (PGE2, PGI2 and PGF2,:) and thromboxane A2 was investigated in short term incubates of duodenal mucosa biopsies. Mucosa close to the ulcer site synthesised significantly less PGF2a (p<0.001) and PGI2 (p<0-002) measured as its stable metabolite 6-oxo-PGF1, than healthy mucosa from non-ulcer patients. In paired biopsies taken from the ulcer site and opposite the ulcer ...

conclusions our results showed that mo extract may have a gastroprotective effect against experimental gastric ulcers in rats. the exact mechanism has not yet been determined, but it may be due to enhancing enzymatic antioxidant defenses and inhibiting lipid peroxidation. materials and methods male wistar rats (200 - 250 g) were starved for 24 hours prior to the induction of gastric ulceration ...