The current processing paradigm of large manufacturing facilities dedicated to single product production is no longer an effective approach for best manufacturing practices. Increasing competition for new indications and the launch of biosimilars for the monoclonal antibody market have put pressure on manufacturers to produce at lower cost. Single-use technologies and continuous upstream proces...

In this paper, the relationship between operations strategy and performance through ̄exibility as a moderating variable is analysed within the service setting of engineering consulting ®rms in Spain. A framework for service strategy dimensions is suggested while manufacturing ̄exibility dimensions are applied to service operations considering necessary adaptations. A path analysis model is applie...

In the globalization era each and every organization which wants to compete the world’s changing scenario has to adopt changes with time. In case of globalization, privatization and liberalization old traditional strategies of manufacturing and management have already changed. There are no cross border bearers and giants which can operate their operations from more than one country availing...

In recent years, flexible manufacturing system as a response to market demands has been proposed to increase product diversity, optimum utilization of machines andperiods of short-term products.The development of computer systems has provided the ability to build machines with high functionality and the necessary flexibility to perform various operations. However, due to the complexity and the ...

Organising efficiently all the resources required for manufacturing has derived considerable attention of both researchers and practitioners over the last several decades. Beginning from a functionally focused approach several alternatives have been suggested using principles of Group Technology and Cellular Manufacturing. This paper seeks to address the problems that are yet to be addressed an...

Computer-aided process planning (CAPP) is an essential component in linking computer-aided design (CAD) and computer-aided manufacturing (CAM). Operation sequencing in CAPP is an essential activity. Each sequence of production operations which is produced in a process plan cannot be the best possible sequence every time in a changing production environment. As the complexity of the product incr...

The Computer-Aided Manufacturing Engineering (CAME) program is developing a number of integrated software toolkits for design, manufacturing engineering, and production operations [1]. One of these toolkits is the Manufacturing Engineering ToolKit (METK) [2]. The goals of the METK project are 1) to develop generic interface specifications, data structures, information models, and data validatio...

TWO-MACHINE FLOWSHOP SCHEDULING WITH FLEXIBLE OPERATIONS AND CONTROLLABLE PROCESSING TIMES Zeynep Uruk M.S. in Industrial Engineering Advisor: Prof. Dr. Selim Aktürk Co-Advisor: Asst. Prof. Dr. Hakan Gültekin August, 2011 In this study, we consider a two-machine flowshop scheduling problem with identical jobs. Each of these jobs has three operations, where the first operation must be performed ...