نتایج جستجو برای: malonyl coenzyme a decarboxylase
تعداد نتایج: 13436944 فیلتر نتایج به سال:
The fungal type III polyketide synthase 2'-oxoalkylresorcylic acid synthase (ORAS) primes with a range of acyl-Coenzyme A thioesters (C4-C20) and extends using malonyl-Coenzyme A to produce pyrones, resorcinols, and resorcylic acids. To gain insight into this unusual substrate specificity and product profile, we have determined the crystal structures of ORAS to 1.75 A resolution, the Phe-252-->...
After years of inadequate use and the emergence of multidrug resistant (MDR) strains, the efficiency of "classical" antibiotics has decreased significantly. New drugs to fight MDR strains are urgently needed. Bacteria hold much promise as a source of unusual bioactive metabolites. However, the potential of marine bacteria, except for Actinomycetes and Cyanobacteria, has been largely underexplor...
The tumor suppressor p53 has recently been shown to regulate energy metabolism through multiple mechanisms. However, the in vivo signaling pathways related to p53-mediated metabolic regulation remain largely uncharacterized. By using mice bearing a single amino acid substitution at cysteine residue 305 of mouse double minute 2 (Mdm2(C305F)), which renders Mdm2 deficient in binding ribosomal pro...
The requirement for bicarbonate in the incubation medium for the conversion of octanoic acid to stearic acid by slices of liver tissue was reported some 10 years ago (1). Furthermore, the inclusion of bicarbonate in the homogenizing medium permitted the preparation of a consistently active enzyme system from pigeon liver which catalyzed the conversion of acetate or acetyl coenzyme A to long cha...
Leptin secretion by adipose tissue is involved in many physiological control systems, including those that determine growth, development, body composition, milk production, and reproductive function. In the adipocyte of monogastric animals, malonyl CoA (coenzyme A) seems to link the flux of energy substrates to the control of leptin production. In this study, we tested this for ruminants by exa...
This over-all equation is thought to consist of the repetition of a series of reactions, each series being initiated by the condensation of malonyl coenzyme A with an unsubstituted straight chain acyl compound to form ,&ketoacyl-S-enzyme (5, 8). A series is then presumably concluded by reactions in which the P-ketoacyl compound is reduced and dehydrated to form an acyl compound 2 carbon atoms l...
A 3-hydroxypropionate/4-hydroxybutyrate cycle operates during autotrophic CO(2) fixation in various members of the Crenarchaea. In this cycle, as determined using Metallosphaera sedula, malonyl-coenzyme A (malonyl-CoA) and succinyl-CoA are reductively converted via their semialdehydes to the corresponding alcohols 3-hydroxypropionate and 4-hydroxybutyrate. Here three missing oxidoreductases of ...
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