a survey of malignant lymphoid tumors among iranians the frequency. histopathologic features, and clinical aspects of malignant lymphoid tumors. among iranians arc discussed on the basis of 68,000 consecutive biopsies and 1917 autopsies performed over a twenty.five years period in the department of pathology at teheran university. of the 5814 lymph nodes examined on biopsy, 1368 (23%) showed ma...

INTRODUCTION Recent scientific attention has focused on the role of growth factors in the progression of cancer. HER-2/neu is an epidermal growth factor receptor that is demonstrated to have correlation with poor prognosis of many cancers. This study evaluated the overexpression of HER-2/neu protein and its clinical importance in nonseminomatous germ cell tumors of the testis. MATERIALS AND M...

BACKGROUND Testicular tumors are the most common genital neoplasms in male dogs, with Leydig cell tumors (LCT), seminomas (SEM), and Sertoli cell tumors (SCT) the most common forms. Human SEM are classified as classical (CSEM) or spermatocytic (SSEM). Intratubular germ cell neoplasia of undifferentiated origin (IGCNU) is another form of human testicular tumor. The aim of this study was to verif...

Malignant ovarian tumors are very rare during childhood and adolescence where their incidence is approximately 0.71 per 100,000. We reviewed the symptoms, histologic subtypes, diagnostic evaluation and management of ovarian tumours in children and adolescents with emphasis on malignant tumours. The histology of these tumours is complex and their diagnosis frequently poses problems. Surgery and ...

Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumor occurring in females of reproductive age. It is typically benign, but rare malignant transformations have been reported in 1-2% of the cases. Among a wide variety of malignancies arising in MCTs, high grade lymphomas are the least common. We present a case of a 45- years -old female with a unilateral adnexal ma...

Germ cell tumors account for less than 3% of all ovarian cancers. These tumors generally appear in childhood or in those under 30 years of age. Immature ovarian teratoma is the third most frequent germ cell tumor after dysgerminoma and endodermal sinus tumors. These tumors should be distinguished from mature teratomas. Discrimination of malignant and benign tumors depends on the presence of the...

The aim of this study was to evaluate the role of fine needle aspiration cytology in the diagnosis of abdominal and retroperitoneal masses in children on this study. In 53 cases of childhood abdominal and retroperitoneal masses within a 4 year period (1998- 2001) preoperative fine needle aspiration was done under the guide of CT scan. 2 pathologists reviewed fine needle aspiration smears. I...

A recent exome-sequencing study revealed prevalent mitogen-activated protein kinase 1 (MAPK1) p.E322K mutation in cervical carcinoma. It remains largely unknown whether ovarian carcinomas also harbor MAPK1 mutations. As paralogous gene mutations co‑occur frequently in human malignancies, we analyzed here a total of 263 ovarian carcinomas for the presence of MAPK1 and paralogous MAPK3 mutations ...

A late-relapse germ cell tumor might contain malignant non-germ cell tumors, known as 'somatic-type malignancy (SM)'. The development of a secondary SM is rare, and this phenomenon remains poorly understood. Case 1 developed lung metastasis 13 years after chemotherapy followed by retroperitoneal lymph node dissection for stage IIA non-seminoma. The tumor increased in size after chemotherapy. Th...