Genetic changes during tumorigenesis are usually acquired sequentially. However, a recent study showed that in 2% to 3% of all cancers a single catastrophic event, termed chromothripsis, can lead to massive genomic rearrangements confined to one or a few chromosomes. To explore whether the degree of genomic instability and chromothripsis influences prognosis in cancer, we retrospectively applie...

Ischemic Stroke and Tissue Hypodensity on Computed Tomography To the Editor: Clinical experience and experimental data have shown that early identification of patients with a large ischemic brain edema and subsequent hemicraniectomy can decrease mortality and morbidity.1,2 I read with great interest the article by Haring and colleagues3 and appreciate the efforts of the authors to find CT crite...

Background: Malignant neoplasms remain the second leading cause of death in children after accidents. The aim of this study was to assess the epidemiology of childhood cancer in children admitted to Dr sheikh hospital, Iran. Materials and Methods: This descriptive cross- sectional study had been done in Dr Sheikh Hospital in Mashhad University of medical science on 1764 children younger than 1...

protein losing enteropathy (ple) as an initial finding of lymphoma, is extremely rare in childhood. we describe clinical and pathological features of an unusual case of gastrointestinal lymphoma presented with ple as a sole manifestation. differential diagnosis in children presenting with ple is critical because early diagnosis and treatment are important for survival in patients with lymphoma.

vitiligo is a disease that results in depigmented areas in the skin. it may develop at any age but the average age at onset is 20 years. association of vitiligo and melanoma has been commonly reported, but malignancies other than melanoma have been rarely associated with vitiligo. we report a 73‑year‑old patient with new onset vitiligo who developed esophageal adenocarcinoma in the following ye...

introduction: the incidence of malignant melanoma is increasing at a rate greater than any other human cancer. although melanoma accounts for only 4 percent of all dermatologic cancers, it is responsible for 80 percent of deaths from skin cancer; only 14 percent of patients with metastatic melanoma survive for five years. the optimal therapy varies with the stage of the disease. surgical excisi...

abstract primary cardiac tumors are rare in all ages. their reported prevalence ranges from 0.001 to 0.03 percent in autopsy series. 25 percent of primary cardiac tumors are considered to be malignant, the majority of which are sarcomas. on account of the late presentation of symptoms in malignant heart masses, finding locally infiltrative tumors or systemically widespread cases at initial pres...

introduction: different imaging modalities are used to evaluate salivary gland diseases, including tumors. ultrasonography (us) is the preferred method on account of its ease of use, affordability, safety profile, and good tolerance among patients. the aim of this study was to evaluate the role of us in differentiating malignant from benign parotid tumors, in the context of previous controversy...

Based on the accumulated data, FTIR spectroscopy seems to be a highly sensitive tool in cervical cancer diagnosis. We, therefore, employed this technique in a screening type of research here in Tehran. The purpose of this study was to look for the spectral pattern differences between normal and malignant cervix samples in Iranian women. Through formal and informal announcements, all gynecology ...

Neuroendocrine tumors are a rare and heterogeneous group of neoplasms with different malignant potential. They often metastasize to the liver require active combined therapy. For unresectable neuroendocrine metastases, transplantation has become potential definitive treatment due slow growth clinical course metastatic process. We conducted review relevant literature, criteria for including excl...