Edward’s syndrome is commonly known as the trisomy 18 syndrome. It a devastating genetic disorder that can be characterized by multiple congenital anomalies. About 50% babies with this do not survive beyond one week of age and approximately 95% does past first year life. The feature Syndrome involves in craniofacial, skeletal, cardiovascular, central nervous system genitourinary malformations. ...

ABSTRACT The umbilical cord constriction (UCC) is an uncommon condition and important etiology for stillborn fetuses. main goal of this study was to verify the UCC occurrence as cause intrauterine fetal death, associated its pathological characteristics. Therefore, a descriptive retrospective cross-sectional developed using database from Pathology Institute, in Brazil, 1995 2017. results presen...

Vascular malformations are a disruption of the normal vascular pattern in which it is expected that a capillary network of microscopic vessels lies interposed between high-pressure arteries that deliver blood and thin-walled veins that collect low-pressure blood for return to the heart. In the case of arteriovenous malformations, arteries or arterioles connect directly to the venous collection ...

OBJECTIVE To review the association between congenital heart defects and extracardiac malformations. DATA SOURCES Scientific articles were searched in the Medline, Lilacs, and SciELO databases, using the descriptors "congenital heart disease," "congenital heart defects," "congenital cardiac malformations," "extracardiac defects," and "extracardiac malformations." All case series that specific...

BACKGROUND The epidemiological profile of mortality in a population is important for the institution of measures to improve health care and reduce mortality Objective: To estimate mortality rates and the proportional mortality from cardiovascular diseases and malformations of the circulatory system in children and adolescents. METHODS This is a descriptive study of mortality from cardiovascul...

INTRODUCTION A number of investigations have been made of the estimation of the incidence of central nervous system (CNS) malformations. Several of these studies (e.g. McKeown and Record, Ciba Foundation, 1960) have stressed the association of malformations (e.g. spina bifida with anencephalus or hydrocephalus). The possible effects of birth order upon these malformations have been commented up...

BACKGROUND There is an association between extreme maternal ages and the risk of congenital malformations. This is specially true for chromosomal abnormalities among women of advanced ages and disruptive malformation among teenage mothers. AIM To determine the association between maternal ages and incidence of congenital malformations at the obstetric ward of a clinical hospital. To compare t...

INTRODUCTION A number of investigations have been made of the estimation of the incidence of central nervous system (CNS) malformations. Several of these studies (e.g. McKeown and Record, Ciba Foundation, 1960) have stressed the association of malformations (e.g. spina bifida with anencephalus or hydrocephalus). The possible effects of birth order upon these malformations have been commented up...

Background: Areas of microvascular proliferation have been observed in a subpopulation of symptomatic congenital vascular malformations later in life. We investigated whether this angiogenic response is followed by a stage of maturation. Methods: Resections of vascular malformations (n=15), infantile hemangiomas (n=8) and pyogenic granulomas (n=5) were studied. Histopathologically, all lesions ...

OBJECTIVES To develop clinical criteria that permit clinical distinction between inherited glomuvenous malformation (GVM), known as glomangioma, and inherited cutaneomucosal venous malformation and to test these criteria on sporadic lesions. DESIGN Clinical data were compiled for 1685 patients with inherited or sporadic cutaneous venous anomalies. Based on a cohort of patients with a mutation...