The review published by Kläver and Gromoll is a timely reminder of the everchanging landscape of the clinical andrology laboratory as well as the limitations of current approaches to properly diagnose and treat male infertility.1 In a variety of disciplines, the clinical relevance of epigenetic status is becoming increasingly apparent. In this paper, the authors review the various studies that ...

Male infertility is one important factor among the multifactorial causes of couple infertility, being oxidative stress main related sources. Sperm a specialized cell extremely susceptible to stress. To understand and mitigate this event, many studies have used different antioxidants, orally or in vitro supplementation, trying improve sperm quality function. Considering extensive available liter...

Stimulated intrauterine insemination (IUI) should be the first choice treatment for mild male factor infertility, unexplained infertility or minimal to mild endometriosis. In mild male factor infertility, unexplained infertility, IUI is as effective as IVF & at 1/3 of the cost per pregnancy. In couples with the most severe semen defects, IUI in natural cycle should be the treatment of choice. I...

INTRODUCTION Obesity has become a major problem in most developed countries. Infertility ranks high among the issues brought by excessive weight gain, particularly as it may affect male sexual function. This study investigated a population of Brazilian infertile men in an attempt to establish a relationship between obesity and infertility. METHODS A total of 153 infertile men had their anthro...

© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2016;5(S1) tau.amegroups.com 50%. With the recent advances in assisted fertilization such as in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), the couples suffer from infertility would like to choose assisted fertilization and nearly 1 million cycles ICSI were carried out in China every year, eve...

Females that are socially bonded to a single male, either in a social monogamy or in a social polygyny, are often sexually polyandrous. Extrapair copulations (EPC) have often been suggested or rejected, on both empirical and theoretical grounds, as an important mechanism that enables females to avoid fertility risks in case their socially bonded male is infertile. Here, we explore this possibil...

BACKGROUND In recent years, oxidative stress has been studied extensively as a main contributing factor to male infertility. Nitric Oxide, a highly reactive free radical gas, is potentially detrimental to sperm function and sperm DNA integrity at high levels. Thus, the aim of this study was to investigate the associations between five polymorphisms in nitric oxide synthase genes (NOSs) and the ...

BACKGROUND Alterations at the molecular level in spermatozoa and seminal plasma can affect male fertility. The objective of this study was to determine if analysis of differential expression of proteins in varying semen parameters can serve as potential biomarkers for male infertility. METHODS The differential expression of proteins in the seminal plasma of men based on sperm count and morpho...

M ale reproductive dysfunction is the sole or contributory cause of infertility in half of couples making the systematic clinical and laboratory evaluation of the male, and the application of costeffective management strategies tailored to the individual patient’s need, vital parts of fertility practice. Male infertility has a wide range of etiologies and effective approaches to initiate, resto...

STUDY QUESTION Are there DNA methylation alterations in sperm that could explain the reduced biological fertility of male partners from couples with unexplained infertility? SUMMARY ANSWER DNA methylation patterns, not only at specific loci but also at Alu Yb8 repetitive sequences, are altered in infertile individuals compared with fertile controls. WHAT IS KNOWN ALREADY Aberrant DNA methyl...