Liposomes are spherical, self-closed structures formed by lipid bilayers that can encapsulate drugs and/or imaging agents in their hydrophilic core or within their membrane moiety, making them suitable delivery vehicles. We have synthesized a new liposome containing gadolinium-DOTA lipid bilayer, as a targeting multimodal molecular imaging agent for magnetic resonance and optical imaging. We sh...

The aim of this study was to construct redox- and pH-responsive degradable manganese dioxide (MnO2) nanosheets for cancer theranostic application. The small MnO2 nanosheets were synthesized, and then functionalized by hyaluronic acid (HA), demonstrating excellent stability and tumor-targeting ability. Cisplatin (cis-diamminedichloroplatinum [CDDP]) was absorbed by the nanosheets through a physi...

Stem cell transplantation is a promising strategy for therapeutic cardiac regeneration, but current therapies are limited by inefficient interaction between potentially beneficial cells (either exogenously transplanted or endogenously recruited) and the injured tissue. Here we apply targeted nanomedicine to achieve in vivo cell-mediated tissue repair, imaging and localized enrichment without ce...

Although nanorobots may play critical roles for many applications in the human body such as targeting tumoral lesions for therapeutic purposes, miniaturization of the power source with an effective onboard controllable propulsion and steering system have prevented the implementation of such mobile robots. Here, we show that the flagellated nanomotors combined with the nanometer-sized magnetosom...

objective(s):multi-epitopic protein vaccines and direction of vaccine delivery to dendritic cells (dcs) are promising approaches for enhancing immune responses against mutable pathogens. escherichia coli is current host for expression of recombinant proteins, and it is important to optimize expression condition. the aim of this study was the optimization of multi-epitopic hiv-1 tat/pol/gag/env ...

abstract this study is an attempt to investigate the influence of targeting subsidies on price transmission pattern in iran's egg market. the targeting subsidies plan was imposed by 20 december 2010. using of daily price time series data, the study was conducted during december 2009 to october 2011. using ecm model, price transmission models were estimated for the two periods (e.g. before and a...

this paper is devoted to the study of determining optimal process mean in system production with the two markets for the sale of goods. in this paper, we developed an absorbing markov chain model in production systems where all items are inspected %100 for conformance with their specification limits. when the value of the quality characteristic of an item falls below a lower limit, the item is ...

temperature restrictions on aqueous effluents dictate that streams with a temperature higher than the permitted level needed to pass through cooling systems to reduce the effluent temperature before discharge. in this study, by considering the grouping design rules based on pinch technology, an optimum design for a distributed effluent cooling system, has been developed. a counter-flow wet cool...

avicenna (980 – 1037 ad) known as the prince of physicians in the west was one of the most prominent persian thinkers, philosophers, and physicians. owing to his interests in cardiology, he authored considerable works on different aspects of cardiology. “resaley-e-ragshenasi” (book on pulsology) and”kitab al-adviyt- ol-qalbiye” (the book on drugs for cardiovascular diseases) are avicenna’s grea...

background: prostate cancer after lung cancer is the second cause of cancer-associated death in men. in recent years, targeted therapy of cancer has attracted researchers attention. the targeted therapy lead to decrease in side effects of drugs. studies have indicated that targeting peptides for cancer cells represent valuable tools for diagnostic and therapeutic. recently, phage display peptid...