OBJECTIVES The objective of this study was to develop and test computer algorithms to export micro computed tomography (microCT) images and to generate tumour geometry and specific absorption rate (SAR) distribution for heat transfer simulation in magnetic nanoparticle hyperthermia. METHODS Computer algorithms were written to analyse and export microCT images of 3D tumours containing magnetic...

A 55-year-old patient with cancer of the tongue (T2N0M0) was treated by thermochemotherapy using interstitial magnetic induction hyperthermia (Implant Heating System: IHS). The patient received 2 courses of hyperthermia, each of which was 45 minutes long. At the same time, the patient received 2 courses of chemotherapy, which included intra-arterial infusion of 100 mg of cisplatin (CDDP) and 25...

Magnetic properties and heat generation characteristics of a bio-compatible ceramic Mg1þxFe222xTixO4 system have been investigated as an implant material for the magnetic induction hyperthermia. Curie temperature ðTcÞ of the ceramic decreases with increasing x; and become Tc , 350 K at x 1⁄4 0:35 and ,315 K at x 1⁄4 0:38; which is suitable Curie temperature for implant material. The temperature...

The aim of the paper is to show basic ideas of magnetic fluid hyperthermia treatment with regard to power losses which occur during heating with alternating magnetic field. A special attention has been paid to dielectric, hysteresis and relaxation mechanism losses and their contribution to total power losses. A numerical analysis has been done with regard to a simplified female breast phantom a...

Volume 3 • Issue 6 • 1000e112 J Nanomed Nanotechol ISSN:2157-7439 JNMNT an open access journal Magnetic nanoparticles show remarkable phenomena such as superparamagnetism, high field irreversibility and high saturation magnetization [1]. The study of magnetic nanoparticles has been a very active research field due to many important applications such as drug delivery, imaging and hyperthermia ca...

HISTORICAL DEVELOPMENT: The use of hyperthermia (heat) in the treatment of malignant tumors is as old as medicine itself. For example, the 5000-year old Edwin Smith Surgical Papyrus mentions heat as potential treatment for breast cancer [1]. Hippocrates, the father of medicine, proposed that surface tumors should be cauterized by application of hot iron. In modern times, more advanced methods (...

Background: The progress in material science and the recent advances in biodegradable/biocompatible polymers and magnetic iron oxide nanoparticles have led to develop innovative diagnostic and therapeutic strategies for diseases based on multifunctional nanoparticles, which include contrast medium for magnetic resonance imaging, agent for hyperthermia and nanocarriers for targeted drug delivery...

Magnetic nanoparticles are increasingly used for clinical applications such as drug delivery, magnetic resonance imaging and magnetic fluid hyperthermia. A novel method of interstitial heating of tumours following direct injection of magnetic nanoparticles has been evaluated in humans in recent clinical trials. In prostate cancer this approach has been investigated in two separate phase I studi...