Cytotoxicity, a major obstacle in therapeutic application of antimicrobial peptides, is controlled by leucine-zipper-like sequences in melittin and other naturally occurring antimicrobial peptides. Magainin 2 shows significantly lower cytotoxicity than many naturally occurring antimicrobial peptides and lacks this structural element. To investigate the consequences of introducing a leucine zipp...

Axon calibre is crucial to efficient impulse transmission in the peripheral nervous system. Neurofilament numbers determine gross axonal diameter, but intra-axonal distribution depends on the phosphorylation status of neurofilament sidearms. Myelin-associated glycoprotein (MAG) has been implicated in the signalling cascade controlling neurofilament phosphorylation and hence in the control of ax...

CNS regeneration in higher vertebrates is a long sought after goal in neuroscience. The lack of regeneration is attributable in part to inhibitory factors found in myelin (Caroni and Schwab, 1988a). Myelin-associated glycoprotein (MAG) is an abundant myelin protein that inhibits neurite outgrowth in vitro (McKerracher et al., 1994; Mukhopadhyay et al., 1994), but its role in regeneration remain...

We present deep u-, and g-band images taken with the MegaCam on the 3.6 m Canada-France-Hawaii Telescope (CFHT) to support the extragalactic component of the Spitzer First Look Survey (hereafter, FLS). In this paper we outline the observations, present source catalogs and characterize the completeness, reliability, astrometric accuracy and number counts of this dataset. In the central 1 deg2 re...

Different graph generalizations have been recently used in an ad-hoc manner to represent multilayer networks, i.e. systems formed by distinct layers where each layer can be seen as a network. Similar constructions have also been used to represent time-varying networks. We introduce the concept of MultiAspect Graph (MAG) as a graph generalization that we prove to be isomorphic to a directed grap...

In many cancer cells the alteration of glycosylation processes leads to the expression of cryptic carbohydrate moieties, which make them good targets for immune intervention. Identification of cancer-associated glycotopes as well as progress in chemical synthesis have opened up the way for the development of fully synthetic immunogens that can induce anti-saccharide immune responses. Here, we s...

The IgM in three patients with paraproteinemia and peripheral neuropathy was shown to bind to human myelin-associated glycoprotein (MAG) that had been purified to homogeneity by gel filtration on Sepharose CL-6B. The antigenic determinant reacting with the IgM from all three patients was in the carbohydrate part of the MAG molecule. In addition, the IgM from the same three patients bound to a s...

We are gathering archival observations to determine the photometric history of the unique and unexplained eclipses of the pre–main-sequence star KH 15D. Here we present a light curve from 1967–1982, based on photographic plates from Asiago Observatory. During this time, the system alternated periodically between bright and faint states, as observed today. However, the bright state was 0.9 mag b...

The cardiovascular effects of mollic acid glucoside (MAG), a 1alpha-hydroxycycloartenoid saponin extractive from Combretum molle R Br ex G Don (Combretaceae) leaf, have been investigated in some experimental animal paradigms. The plant extract (MAG, 5-80 microg/ml) produced concentration-dependent, significant (p < 0.05-0.001) negative inotropic and negative chronotropic effects on guinea pig i...

— We established a GRB follow-up observation system at the Kiso observatory (Japan) in 2001. Since prior to this the east Asian area had been a blank for in GRB follow-up observational network, this observational system is very important for studying the temporal and spectral evolution of early afterglows. We have thus been able to make quick observations of early phase optical afterglows based...