OBJECTIVE To characterize foveal atrophy in a heterogeneous group of patients with uveitis using clinical findings and high-definition (HD) optical coherence tomography (OCT). DESIGN Cross-sectional, retrospective case series. RESULTS The HD-OCT scans of 140 patients seen in a tertiary referral center were reviewed and 23 patients (33 eyes) with foveal atrophy were identified. All of the pa...

PURPOSE To describe unusual macular abnormalities in a family with blue cone monochromacy (BCM, or X-linked incomplete achromatopsia) and deletion of about 9.5 kb comprising part of the red pigment gene and the region upstream of the red pigment gene. METHODS The molecular structure of the red and green pigment genes and the locus control region (LCR) upstream of the red gene were studied for...

PURPOSE To evaluate the reliability and validity of a portable instrument for measuring macular pigment optical density. METHODS The instrument is small, uses light emitting diodes as light sources and the principles of heterochromatic flicker photometry of comparing foveal and extra-foveal minimum flicker matches. It uses central fixation for the extra-foveal matches, which subjects found ea...

There is a consensus that age-related macular degeneration (AMD) is the result of (photo)-oxidative-induced retinal injury and its inflammatory sequelae, the latter being influenced by genetic background. The dietary carotenoids, lutein (L), zeaxanthin (Z), and meso-zeaxanthin (meso-Z), accumulate at the macula, where they are collectively known as macular pigment (MP). The anatomic (central re...

OBJECTIVE Toxicity of intense light to facilitate the development of neovascular age-related macular degeneration has been a health concern although the mechanism remains unclear. METHODS AND RESULTS Effects of intense, but within physiological range, light on retinal pigment epithelium, a major pathogenic origin of age-related macular degeneration were studied in mice. Intense physiological ...

Although decreased macular pigment density is associated with the development of age-related degeneration (AMD), exactly how this decrease may contribute to AMD still not fully understood. In study, we investigated relationship between optical (MPOD) and estimated glomerular filtration rate (eGFR). MPOD was measured using MPS II (Electron Technology, Cambridge, UK) in 137 participants who showe...

Clinical and pathological examination was performed on 378 eyes from 216 patients aged 43 to 97 years. This series represented eyes in which the fundi were normal or showed various manifestations of senile macular degeneration. The eyes were divided into six groups according to the histological appearance of a linear deposit at the base of the retinal pigment cells. Groups I and II were conside...

by indocyanine green angiography in a patient with retention of good vision for almost four years. Retina. 1994;14:114-124. 3. Borodkin MJ, Thompson JT. Retinal cartography: an analysis of two-dimensional and threedimensional mapping of the retina. Retina. 1992; 12:273-280. 4. Snyder JP. Map Projections: A Working Manual, USGS Professional Paper. Washington, DC: US Government Printing Office; 1...

by indocyanine green angiography in a patient with retention of good vision for almost four years. Retina. 1994;14:114-124. 3. Borodkin MJ, Thompson JT. Retinal cartography: an analysis of two-dimensional and threedimensional mapping of the retina. Retina. 1992; 12:273-280. 4. Snyder JP. Map Projections: A Working Manual, USGS Professional Paper. Washington, DC: US Government Printing Office; 1...