نتایج جستجو برای: macrophage migration inhibitory factor mif

تعداد نتایج: 1102207  

Journal: :Journal of the American Society of Nephrology : JASN 2017
Sonja Djudjaj Ina V Martin Eva M Buhl Nina J Nothofer Lin Leng Marta Piecychna Jürgen Floege Jürgen Bernhagen Richard Bucala Peter Boor

Renal fibrosis is a common underlying process of progressive kidney diseases. We investigated the role of macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory cytokine, in this process. In mice subjected to unilateral ureteral obstruction, genetic deletion or pharmacologic inhibition of MIF aggravated fibrosis and inflammation, whereas treatment with recombinant MIF was b...

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