The in vitro metabolism of temsirolimus, (rapamycin-42-[2,2-bis-(hydroxymethyl)]-propionate), an antineoplastic agent, was studied using human liver microsomes as well as recombinant human cytochrome P450s, namely CYP3A4, 1A2, 2A6, 2C8, 2C9, 2C19, and 2E1. Fifteen metabolites were detected by liquid chromatography (LC)-tandem mass spectrometry (MS/MS or MS/MS/MS). CYP3A4 was identified as the m...

Purpose There has been much research on manufacturing flexibility, but supply chain flexibility is still an under-investigated area. This paper focuses on supply flexibility, the aspects of flexibility related to the upstream supply chain. Our purpose is to investigate why and how firms increase supply flexibility. Methodology/Approach – An exploratory multiple case study was conducted. We anal...

The present study analyzed 21 coding region SNP markers and one deletion motif for the determination of East Asian mitochondrial DNA (mtDNA) haplogroups by designing three multiplex systems which apply single base extension methods. Using two multiplex systems, all 593 Korean mtDNAs were allocated into 15 haplogroups: M, D, D4, D5, G, M7, M8, M9, M10, M11, R, R9, B, A, and N9. As the D4 haploty...

elements include: “no war”, “peace”, “no conflict”, “harmony”, “living happily”, etc. AE1 = “no war”, AE2 = “peace”, AE3 = “no conflict”, AE4 = “harmony”, AE5 = “living happily”, etc. Partial meaning mapping based on the symbol of peace. Peace = “dove” and “symbol by Gerald Holtom”, “the broken riffle”, Harmony = “many” and, etc. M11 = (“peace”, “dove”), M12 = (“peace”, “symbol by Gerald Holtom...

The human cancer antigen 125 (CA125) is over-expressed in epithelial ovarian cancer cells and it plays a role in the pathogenesis of ovarian cancer. This protein presents a repeat region containing up to sixty tandem repeat units. The anti-CA125 monoclonal antibodies have been previously classified into three groups: two major families, the OC125-like antibodies and M11-like antibodies, and a t...

Consider λ to be a connected graph with vertex set id="M2"> V that may partitioned into any partition id="M3"> S . If each in id="M4"> has separate representation regard id="M5"> and is an ordered id="M6"> k partitio...

Let A and id="M2"> mathvariant="script">B be two closed linear relations acting between Banach spaces id="M3"> X id="M4"> Y , let id="M5"> λ a complex number. We study the stability of nullity deficiency id="M6"> when it is perturbed by id="M7"> . In particular, we sho...

The objective of this research is, to explain a new framework navigate the movement robot towards target goal. This involves need for move from initial position 1 out 30 rooms. Therefore strategy used combination room database stored in RFID data using petri net (PN) method simulate and model navigation after which dynamic behavior is moving desired location was analyzed. process started creati...

Algebraic graph theory is the study of interplay between algebraic structures (both abstract as well linear structures) and theory. Many concepts algebra have facilitated through construction graphs which are used tools in computer science. Conversely, has also helped to characterize certain properties structures. In this survey, we highlight rich two topics viz groups power from groups. last d...

Rapid economic growth along with carelessness related to environmental problems have caused adverse impacts on nature and civilization as a whole. The effects include temperature changes increased climactic disasters. To minimize the negative of climate change reduce future emissions, several governments announced charges for greenhouse gas emissions. However, these present extra operational co...