BACKGROUND Bilateral sequential lung transplantation (BSLT) has been widely adopted as an alternative to combined heart and lung transplantation for the management of end stage septic lung disease in many transplant centres. METHODS A retrospective review was undertaken of the first 32 consecutive patients with septic lung disease to undergo BSLT at the Freeman Hospital. RESULTS Between Apr...

cadaver up to six hours after cardiac arrest. J Heart Lung Transplant 1999;18:582–6. [19] Wierup P, Bolys R, Steen S. Gas exchange function one month after transplantation of lungs topically cooled for 2 hours in the non-heart-beating cadaver after failed resuscitation. J Heart Lung Transplant 1999;18:133–8. [20] Steen S, Kimblad PO, Sjöberg T, Lindberg L, Ingemansson R, Massa G. Safe lung pres...

Objectives: The number of lung transplants is increasing year by in China and globally. With the widespread use donation after brainstem death (DBD) donor lungs circulatory (DCD) lungs, donor-derived infection (DDI) poses a major challenge transplantation. Using infected or colonized with carbapenem-resistant Enterobacteriaceae (CRE) may have serious implications lung-transplant recipients. Cur...

Increased levels of the neutrophil chemokine interleukin (IL)-8 in the lungs of severe trauma patients can predict subsequent development of acute respiratory distress syndrome. Because the lungs of brain-dead organ donors can contain high levels of IL-8, we hypothesized that this may predispose to early graft failure in the recipient after lung transplantation. Twenty-six organ donors prospect...

Abstract Background and Aims Cystic fibrosis patients are at high risk for chronic kidney disease (CKD), because of aminoglycoside exposure, protein dietary salt intake, Fibrosis Related Diabetes. Lung transplantation also entails a renal burden in the long run calcineurin inhibitors exposure. We aimed studying function by gold standard glomerular filtration rate (mGFR) before 1 year after lung...

Lung transplantation and lung volume reduction surgery have opened a new therapeutic era for patients with advanced emphysema. In addition to providing impressive clinical benefits, they have helped us better understand how the chest wall and respiratory muscles adapt to chronic hyperinflation. This article reviews the effects of these procedures on respiratory muscle and chest wall function. I...

Many children with idiopathic pulmonary arterial hypertension (IPAH) experience disease progression despite advanced medical therapy. In these children, heart-lung or bilateral lung transplantation (BLTx) remain the only therapeutic options when other treatments fail. Data on functional outcome after BLTx in children with IPAH are limited. We report a multi-center experience of BLTx for pediatr...

Severe adult respiratory distress syndrome (ARDS) is associated with failure to maintain adequate gas exchange. There is increasing success using extracorporeal membrane oxygenation (ECMO) for respiratory failure; the longest reported surviving patient has been supported by ECMO for 57 days. At best about 50% wean from ECMO and should weaning fail their course is fatal. ECMO is generally consid...

BACKGROUND Despite significant advances in organ preservation, surgical techniques and perioperative care, primary graft dysfunction is a serious medical problem in transplantation medicine in general and a specific problem in patients undergoing lung transplantation. As a result, patients develop lung edema, causing reduced tissue oxygenation capacity, reduced lung compliance and increased req...

As the first decade of successful clinical lung transplantation draws to a close, the number of patients who are able to benefit from it continues to increase. Pulmonary transplantation in the pediatric age group is possible for an expanding range of diagnoses currently known to cause end-stage lung disease. However, more experience will be required before the answers to a number of clinical pr...